- 专利标题： CELL LINES FOR VIRUS PRODUCTION AND METHODS OF USE
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申请号： EP18164513.6申请日： 2014-02-05
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公开(公告)号： EP3372685A2公开(公告)日： 2018-09-12
- 发明人: KARPILOW, Jon Michael , OBERSTE, Mark Steven , TRIPP, Ralph A. , TOMPKINS, Stephen M.
- 申请人： University of Georgia Research Foundation, Inc. , The United States of America, as represented by The Secretary, Department of Health and Human Services , Thermo Fisher Scientific Inc.
- 申请人地址： Boyd Graduate Studies Research Center Athens, Georgia 30602-7411 US
- 专利权人： University of Georgia Research Foundation, Inc.,The United States of America, as represented by The Secretary, Department of Health and Human Services,Thermo Fisher Scientific Inc.
- 当前专利权人： University of Georgia Research Foundation, Inc.,The United States of America, as represented by The Secretary, Department of Health and Human Services,Thermo Fisher Scientific Inc.
- 当前专利权人地址： Boyd Graduate Studies Research Center Athens, Georgia 30602-7411 US
- 代理机构： Comoglio, Elena
- 优先权： US201361760895P 20130205; US201361885357P 20131001
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; C12N5/00
摘要：
Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picornavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.
公开/授权文献
- EP3372685A3 CELL LINES FOR VIRUS PRODUCTION AND METHODS OF USE 公开/授权日：2018-10-17
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