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公开(公告)号：EP3372685A3
公开(公告)日：2018-10-17
申请号：EP18164513.6
申请日：2014-02-05
申请人： University of Georgia Research Foundation, Inc. , The United States of America, as represented by The Secretary, Department of Health and Human Services , Thermo Fisher Scientific Inc.
IPC分类号： C12N15/113 , C12N5/00
CPC分类号： A61K39/13 , C12N7/00 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2320/12 , C12N2770/32021 , C12N2770/32034 , C12N2770/32052 , C12N2770/32351 , C12N2770/32651
摘要： Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picornavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.
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公开(公告)号：EP3372685A2
公开(公告)日：2018-09-12
申请号：EP18164513.6
申请日：2014-02-05
申请人： University of Georgia Research Foundation, Inc. , The United States of America, as represented by The Secretary, Department of Health and Human Services , Thermo Fisher Scientific Inc.
IPC分类号： C12N15/113 , C12N5/00
CPC分类号： A61K39/13 , C12N7/00 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2320/12 , C12N2770/32021 , C12N2770/32034 , C12N2770/32052 , C12N2770/32351 , C12N2770/32651
摘要： Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picornavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.
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公开(公告)号：EP2461825A2
公开(公告)日：2012-06-13
申请号：EP10807108.5
申请日：2010-08-04
IPC分类号： A61K39/155 , C07K14/115 , A61K39/12
CPC分类号： C07K14/135 , A61K39/12 , A61K39/155 , A61K2039/5252 , A61K2039/545 , A61K2039/555 , A61K2039/55505 , A61K2039/6081 , C07K14/005 , C12N2760/18522 , C12N2760/18534
摘要： Immunogenic polypeptides corresponding to one or more RSV G glycoproteins, or analogues thereof, are provided as components of vaccines. The inventive compositions are useful as both a prophylactic and therapeutic for the prevention and treatment of RSV infections and associated pulmonary or other diseases. The inventive immunogens include regions of the RSV G protein, specifically, amino acid residues 164-176 of RSV G A2 protein or analogues thereof. This inventive immunogen is operable alone or in combination with other polypeptides such as the RSV G protein amino acid residues 155-206, or other vaccines such as live RSV vaccines, or inactivated RSV vaccines or immunogenic analogues thereof.
摘要翻译： 对应于一种或多种RSV G糖蛋白或其类似物的免疫原性多肽作为疫苗的组分提供。 本发明的组合物可用作预防和治疗RSV感染和相关肺或其它疾病的预防和治疗。 本发明的免疫原包括RSV G蛋白的区域，特别是RSV G A2蛋白的氨基酸残基164-176或其类似物。 本发明的免疫原可单独使用或与其它多肽如RSV G蛋白氨基酸残基155-206或其它疫苗例如活RSV疫苗或灭活的RSV疫苗或其免疫原性类似物组合使用。
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公开(公告)号：EP2461825B1
公开(公告)日：2017-05-31
申请号：EP10807108.5
申请日：2010-08-04
申请人： The Government of The United States of America, as represented by the Secretary, Department of Health and Human Services, , The University of Georgia Research Foundation
IPC分类号： A61K39/155 , C07K14/115 , A61K39/12 , C07K14/135
CPC分类号： C07K14/135 , A61K39/12 , A61K39/155 , A61K2039/5252 , A61K2039/545 , A61K2039/555 , A61K2039/55505 , A61K2039/6081 , C07K14/005 , C12N2760/18522 , C12N2760/18534
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公开(公告)号：EP4008343A3
公开(公告)日：2022-08-24
申请号：EP21200485.7
申请日：2018-03-08
发明人： TRIPP, Ralph A.
IPC分类号： A61K39/13 , C12N7/00 , C12N15/113
摘要： Disclosed are compositions and methods for increasing virus production.
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公开(公告)号：EP4008343A2
公开(公告)日：2022-06-08
申请号：EP21200485.7
申请日：2018-03-08
发明人： TRIPP, Ralph A.
IPC分类号： A61K39/13 , C12N7/00 , C12N15/113
摘要： Disclosed are compositions and methods for increasing virus production.
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公开(公告)号：EP3972995A1
公开(公告)日：2022-03-30
申请号：EP20731725.6
申请日：2020-05-20
发明人： MOUSA, Jarrod , TRIPP, Ralph A. , HUANG, Jiachen
IPC分类号： C07K16/10 , A61K39/12 , A61K39/155
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公开(公告)号：EP4205760A1
公开(公告)日：2023-07-05
申请号：EP23157343.7
申请日：2018-03-08
发明人： TRIPP, Ralph A.
IPC分类号： A61K39/13 , C12N7/00 , C12N15/113
摘要： Disclosed are compositions and methods for increasing virus production.
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公开(公告)号：EP4132503A1
公开(公告)日：2023-02-15
申请号：EP21785329.0
申请日：2021-04-09
IPC分类号： A61K31/195 , A61P31/14
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公开(公告)号：EP3598865A1
公开(公告)日：2020-01-29
申请号：EP18763588.3
申请日：2018-03-08
发明人： TRIPP, Ralph A.
IPC分类号： A61K39/13 , C12N7/00 , C12N15/113
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