- 专利标题： ECHINOMYCIN FORMULATION, METHOD OF MAKING AND METHOD OF USE THEREOF
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申请号： EP16864923.4申请日： 2016-11-09
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公开(公告)号： EP3373910A1公开(公告)日： 2018-09-19
- 发明人: LIU, Yang , WANG, Yin , LIU, Yan , BAILEY, Christopher , ZHENG, Pan
- 申请人： Children's Research Institute, Children's National Medical Center
- 申请人地址： 111 Michigan Ave. NW Washington, DC 20010 US
- 专利权人： Children's Research Institute, Children's National Medical Center
- 当前专利权人： Children's Research Institute, Children's National Medical Center
- 当前专利权人地址： 111 Michigan Ave. NW Washington, DC 20010 US
- 代理机构： TL Brand & Co
- 优先权： US201562253257P 20151110
- 国际公布： WO2017083403 20170518
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; A61K31/395 ; A61K35/74 ; A61K38/08 ; A61K38/12
摘要：
A liposomal drug formulation for treating a disease in a patient characterized by overexpression of HIF-1α and/or HIF-2α includes a plurality of liposomes in a pharmaceutically acceptable carrier. The liposomes encapsulate echinomycin and are made from a peglyated phospholipid, a neutral phosphoglyceride, and a sterol. The PEGylated liposomes may be used to treat proliferative diseases, leukemia, cancer, autoimmune diseases and graft-versus-host disease.
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