公开(公告)号：EP3337491A1

公开(公告)日：2018-06-27

申请号：EP16837853.7

申请日：2016-08-18

申请人： Children's Research Institute, Children's National Medical Center

发明人： LIU, Yang ,  WANG, Yin

IPC分类号： A61K35/28 ,  A61P37/00 ,  A61P37/06 ,  C12N5/0789

CPC分类号： A61K35/28 ,  A61K31/7105 ,  A61K38/08 ,  A61K38/1709 ,  A61K48/005 ,  A61K2300/00 ,  A61P35/02 ,  A61P37/06

摘要： A method of preventing the development of GvHD or reducing the severity of GvHD in a mammalian subject receiving an allogeneic hematopoietic stem cell (HSC) transplant includes administering to the subject a pharmaceutical composition comprising an active agent that inhibits the biological activity or expression of hypoxia-inducible factor-1a (HIF-1a) or hypoxia-inducible factor-2a (HIF-2a), wherein the active agent is administered in an amount effective for preventing or reducing the severity GvHD in the subject.

公开(公告)号：EP3373910A1

公开(公告)日：2018-09-19

申请号：EP16864923.4

申请日：2016-11-09

申请人： Children's Research Institute, Children's National Medical Center

发明人： LIU, Yang ,  WANG, Yin ,  LIU, Yan ,  BAILEY, Christopher ,  ZHENG, Pan

IPC分类号： A61K9/127 ,  A61K31/395 ,  A61K35/74 ,  A61K38/08 ,  A61K38/12

CPC分类号： A61K9/1271 ,  A61K9/1277 ,  A61K35/74 ,  A61K38/164 ,  A61K47/6911 ,  A61P35/02 ,  A61P37/02

摘要： A liposomal drug formulation for treating a disease in a patient characterized by overexpression of HIF-1α and/or HIF-2α includes a plurality of liposomes in a pharmaceutically acceptable carrier. The liposomes encapsulate echinomycin and are made from a peglyated phospholipid, a neutral phosphoglyceride, and a sterol. The PEGylated liposomes may be used to treat proliferative diseases, leukemia, cancer, autoimmune diseases and graft-versus-host disease.