- 专利标题： METHODS FOR DIFFERENTIATING CELLS INTO HEPATIC STELLATE CELLS
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申请号： EP16804820.5申请日： 2016-12-01
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公开(公告)号： EP3384011A1公开(公告)日： 2018-10-10
- 发明人: VERFAILLIE, Cathérine , BOON, Ruben , SANCHO BRU, Pau , COL LOPERENA, Mar , PEREA SANCHEZ, Luis
- 申请人： Katholieke Universiteit Leuven , Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- 申请人地址： K.U. Leuven R&D Waaistraat 6 Box 5105 3000 Leuven BE
- 专利权人： Katholieke Universiteit Leuven,Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- 当前专利权人： Katholieke Universiteit Leuven,Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- 当前专利权人地址： K.U. Leuven R&D Waaistraat 6 Box 5105 3000 Leuven BE
- 代理机构： LC Patents
- 优先权： GB201521179 20151201
- 国际公布： WO2017093418 20170608
- 主分类号： C12N5/075
- IPC分类号： C12N5/075 ; C12N5/077
摘要：
The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other applications, for treatment of liver deficiencies, liver metabolism studies, and liver toxicity studies, fibrogenic studies, or to support hepatocyte function in co-culture setting.
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