公开(公告)号：EP3384011B1

公开(公告)日：2020-11-25

申请号：EP16804820.5

申请日：2016-12-01

申请人： Katholieke Universiteit Leuven ,  Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)

发明人： VERFAILLIE, Cathérine ,  BOON, Ruben ,  SANCHO BRU, Pau ,  COL LOPERENA, Mar ,  PEREA SANCHEZ, Luis

IPC分类号： C12N5/071 ,  C12N5/075 ,  C12N5/077

公开(公告)号：EP3384011A1

公开(公告)日：2018-10-10

申请号：EP16804820.5

申请日：2016-12-01

申请人： Katholieke Universiteit Leuven ,  Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)

发明人： VERFAILLIE, Cathérine ,  BOON, Ruben ,  SANCHO BRU, Pau ,  COL LOPERENA, Mar ,  PEREA SANCHEZ, Luis

IPC分类号： C12N5/075 ,  C12N5/077

CPC分类号： C12N5/067 ,  C12N5/0672 ,  C12N2501/113 ,  C12N2501/119 ,  C12N2501/155 ,  C12N2501/385 ,  C12N2501/999 ,  C12N2506/45 ,  C12N2513/00

摘要： The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other applications, for treatment of liver deficiencies, liver metabolism studies, and liver toxicity studies, fibrogenic studies, or to support hepatocyte function in co-culture setting.

公开(公告)号：EP3638772A1

公开(公告)日：2020-04-22

申请号：EP18733219.2

申请日：2018-06-15

申请人： Katholieke Universiteit Leuven

发明人： BOON, Ruben ,  VERFAILLIE, Cath rine

IPC分类号： C12N5/00 ,  C12N5/071 ,  C12Q1/02