- 专利标题: VACCINE ANTIGEN WITH INCREASED IMMUNOGENICITY
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申请号: EP16870730.5申请日: 2016-11-30
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公开(公告)号: EP3385286A1公开(公告)日: 2018-10-10
- 发明人: SAWADA, Kazutoshi , MATSUI, Takeshi
- 申请人: Idemitsu Kosan Co., Ltd.
- 申请人地址: 1-1 Marunouchi 3-chome Chiyoda-ku Tokyo 100-8321 JP
- 专利权人: Idemitsu Kosan Co., Ltd.
- 当前专利权人: Idemitsu Kosan Co., Ltd.
- 当前专利权人地址: 1-1 Marunouchi 3-chome Chiyoda-ku Tokyo 100-8321 JP
- 代理机构: Vossius & Partner Patentanwälte Rechtsanwälte mbB
- 优先权: JP2015233714 20151130; JP2016023090 20160209
- 国际公布: WO2017094793 20170608
- 主分类号: C07K19/00
- IPC分类号: C07K19/00 ; A01H5/00 ; A23K20/195 ; A61K36/28 ; A61K39/00 ; A61P37/04 ; C07K14/245 ; C07K14/28 ; C07K14/405 ; C12N15/09
摘要:
According to the invention, immunogenicity of an antigenic peptide is increased by administering a fusion protein, which comprises an antigenic peptide and an adjuvant protein, wherein the adjuvant protein comprises two or more proteins selected from the group consisting of a Shiga toxin 2e B subunit (Stx2eB), an Escherichia coli heat-labile toxin B subunit (LTB), and a cholera toxin B subunit (CTB). or a transformant transformed by a gene coding for the fusion protein.
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