公开(公告)号：EP4373941A1

公开(公告)日：2024-05-29

申请号：EP22846611.6

申请日：2022-07-21

申请人： Prolific Machines Inc.

发明人： KENT, Deniz ,  HUISMAN, Maximiliaan ,  JONES, Declan ,  JONES, Victor ,  HOOLEY, Monique ,  GALE, Emily ,  PATON, William C.

IPC分类号： C12N15/62 ,  C12N15/85 ,  C12N5/0775 ,  C12N5/10 ,  C07K14/405 ,  C07K14/71

CPC分类号： C07K14/71 ,  C12N15/85 ,  C07K14/50 ,  C07K2319/4320130101 ,  C07K2319/6020130101 ,  C12N13/00 ,  C12N5/0653 ,  C12N5/0658 ,  C12N2501/11520130101 ,  C12N2510/0020130101 ,  C12N2800/9020130101 ,  C12N15/90

公开(公告)号：EP4223768A1

公开(公告)日：2023-08-09

申请号：EP22155173.2

申请日：2022-02-04

申请人： Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin ,  OptoGenTech GmbH

发明人： MOSER, Tobias, Dr. ,  MAGER, Thomas, Dr. ,  ZERCHE, Maria, Dr.

IPC分类号： C07K14/405 ,  G01N33/50

摘要： The present invention relates to a mutant ion channel capable of being activated by light (light-activated' ion channel) and having improved properties, nucleic acids and expression vectors encoding the mutant ion channel, cells comprising such nucleic acid or expression vector, devices containing the mutant ion channel, nucleic acid or expression vector as well as respective uses and methods.

公开(公告)号：EP3921333A1

公开(公告)日：2021-12-15

申请号：EP20702668.3

申请日：2020-02-07

申请人： Fermentalg

发明人： CAGNAC, Olivier ,  ATHANE, Axel ,  DEMOL, Julien ,  BROSSET-VINCENT, Sandra

IPC分类号： C07K14/405 ,  C12N1/06 ,  C12N1/12 ,  C12P17/18 ,  A23L33/195

公开(公告)号：EP3129493B1

公开(公告)日：2021-07-07

申请号：EP15777242.7

申请日：2015-04-09

发明人： ROMESBERG, Floyd, E. ,  MALYSHEV, Denis, A.

IPC分类号： C12P19/34 ,  C07H21/04 ,  C12N15/10 ,  C12N15/70 ,  C07K14/295 ,  C07K14/405 ,  A01H1/00

公开(公告)号：EP3581580A1

公开(公告)日：2019-12-18

申请号：EP19156461.6

申请日：2015-03-27

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： DEISSEROTH, Karl A. ,  LEE, Soo Yeun ,  RAMAKRISHNAN, Charu ,  BERNDT, Andre

IPC分类号： C07K14/405 ,  A61N5/06 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C12N15/00 ,  C12N5/071 ,  A61K41/00

摘要： Aspects of the disclosure include compositions, devices, systems and methods for optogenetic modulation of action potentials in target cells. The subject devices include light-generating devices, control devices, and delivery devices for delivering light-responsive polypeptides, or nucleic acids encoding same, to target cells. The subject compositions and systems include light-activated polypeptides, nucleic acids comprising nucleotide sequences encoding these polypeptides, as well as expression systems that facilitate expression of these polypeptides in target cells. Also provided are methods of using the subject devices and systems to optogenetically manipulate action potentials in target cells, e.g., to treat a neurological or psychiatric condition in a human or animal subject.

公开(公告)号：EP3504227A1

公开(公告)日：2019-07-03

申请号：EP17767952.9

申请日：2017-08-29

申请人： Wayne State University

发明人： PAN, Zhuo-Hua

IPC分类号： C07K14/405 ,  C07K14/705 ,  A61K41/00 ,  A61K35/30 ,  A61K35/34

公开(公告)号：EP3475295A1

公开(公告)日：2019-05-01

申请号：EP17816348.1

申请日：2017-06-23

申请人： The Scripps Research Institute

发明人： ROMESBERG, Floyd E. ,  ZHANG, Yorke

IPC分类号： C07K14/405 ,  C12N9/22 ,  C12N15/10 ,  C12N15/113 ,  C12N15/90

公开(公告)号：EP3193821B1

公开(公告)日：2019-01-02

申请号：EP15771178.9

申请日：2015-08-28

申请人： Algobiotech

发明人： BEN OUADA, Hatem ,  AMMAR, Jihene

IPC分类号： A61K38/16 ,  A61K8/34 ,  A61K8/64 ,  A61Q19/08 ,  C07K14/195 ,  C07K14/405 ,  A61Q17/04 ,  A61Q19/02 ,  A61K35/748 ,  A23L33/195 ,  A61K8/9706 ,  A61Q19/00

公开(公告)号：EP2635111B1

公开(公告)日：2018-05-23

申请号：EP11838898.2

申请日：2011-11-04

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： DEISSEROTH, Karl ,  YIZHAR, Ofer ,  FENNO, Lief

IPC分类号： A01K67/027 ,  C07K14/405 ,  G01N33/50

CPC分类号： A01K67/0275 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0393 ,  C07K14/405 ,  C12N5/0619 ,  C12N2740/16043 ,  C12N2750/14143 ,  G01N33/5088 ,  G01N33/5091

摘要： Provided herein are compositions comprising non-human animals comprising neurons expressing stabilized step function opsin proteins on neural plasma membranes and methods of using the same to selectively depolarize neurons residing in microcircuits of the pre-frontal cortex to affect one or more social behaviors, communications, and/or conditioned behaviors in the non-human animal.

公开(公告)号：EP2764017B1

公开(公告)日：2018-01-10

申请号：EP12838474.0

申请日：2012-10-04

申请人： Ben Gurion University of The Negev Research and Development Authority

发明人： GRUNDMAN, Omer ,  KHOZIN-GOLDBERG, Inna ,  HACOHEN, Zvi ,  SHAPIRA, Michal ,  RAVEH, Dina ,  BOUSSIBA, Sammy ,  ZORIN, Boris

IPC分类号： C07K14/405 ,  C12P13/06 ,  C12P13/08 ,  C12N1/13 ,  C12N15/54 ,  C12N15/82 ,  C12N15/63 ,  C12N9/10 ,  C12P7/64

CPC分类号： C12N9/93 ,  C12N9/0071 ,  C12N9/1022 ,  C12N15/52 ,  C12N15/8251 ,  C12N15/8274 ,  C12P7/6427 ,  C12P7/6463 ,  C12P7/6472 ,  C12Y202/01006

摘要： The present invention provides a protein, specifically Parietochloris incisa acetohydroxyacid synthase, and methods for producing branched-chain amino acid in a cell. The present invention further provides polypeptides and polynucleotides useful for conferring herbicide resistance in a cell or an organism. In particular, the present invention discloses a mutated acetohydroxyacid synthase which is resistant to herbicides.