- 专利标题： PROCESS AND INTERMEDIATES FOR PREPARATION OF THIAZINE DERIVATIVES
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申请号： EP16826192.3申请日： 2016-12-22
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公开(公告)号： EP3394042A1公开(公告)日： 2018-10-31
- 发明人: ONODERA, Naohiro , NOGUCHI, Kouichi , ANDO, Shigeru , NAGAMATSU, Daiki , ISHIBASHI, Kenichi , OCHI, Shunsuke , HASEGAWA, Aiko , ODA, Katsuo
- 申请人： Shionogi & Co., Ltd
- 申请人地址： 1-8, Doshomachi 3-chome Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 专利权人： Shionogi & Co., Ltd
- 当前专利权人： Shionogi & Co., Ltd
- 当前专利权人地址： 1-8, Doshomachi 3-chome Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 代理机构： Vossius & Partner Patentanwälte Rechtsanwälte mbB
- 优先权： JP2015254844 20151225
- 国际公布： WO2017111042 20170629
- 主分类号： C07D279/06
- IPC分类号： C07D279/06 ; C07D417/12
摘要：
The present invention provides a process for preparation of the compound of formula (VI), wherein each symbol is as defined in the specification, without using any intermediate compound showing mutagenicity. The process comprises salt formation of the intermediate compound of formula (I) with acid to enable optical resolution to isolate the intermediate compound of formula (II) in a stereo-selective manner.
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