专利检索 ap:("Shionogi & Co., Ltd") AND inv:"ISHIBASHI, Kenichi" 第 1 页

1.

发明公开
SALT OF QUINAZOLINE DERIVATIVE OR CRYSTAL THEREOF, AND METHOD FOR PRODUCING SALT OF QUINAZOLINE DERIVATIVE OR CRYSTAL THEREOF 审中-公开

公开(公告)号：EP3330267A1

公开(公告)日：2018-06-06

申请号：EP16830581.1

申请日：2016-07-28

申请人： Shionogi & Co., Ltd.

发明人： TADA, Yukio , TAMURA, Yuusuke , YONEZAWA, Shuji , ISHIBASHI, Kenichi , MURAKAMI, Yuki

IPC分类号： C07D413/12 , A61K31/5377 , A61P35/00 , A61P43/00 , C07D265/30

CPC分类号： C07D413/12 , A61K31/5377 , C07B2200/13 , C07D265/30

摘要： Crystals of a quinazoline derivative are provided. The present invention relates to an acid addition salt of a compound represented by Formula (I):

a pharmaceutical composition containing it, and the like.

2.

发明公开
PROCESS AND INTERMEDIATES FOR PREPARATION OF THIAZINE DERIVATIVES 审中-公开

公开(公告)号：EP3394042A1

公开(公告)日：2018-10-31

申请号：EP16826192.3

申请日：2016-12-22

申请人： Shionogi & Co., Ltd

发明人： ONODERA, Naohiro , NOGUCHI, Kouichi , ANDO, Shigeru , NAGAMATSU, Daiki , ISHIBASHI, Kenichi , OCHI, Shunsuke , HASEGAWA, Aiko , ODA, Katsuo

IPC分类号： C07D279/06 , C07D417/12

CPC分类号： C07D279/06 , C07D417/12

摘要： The present invention provides a process for preparation of the compound of formula (VI), wherein each symbol is as defined in the specification, without using any intermediate compound showing mutagenicity. The process comprises salt formation of the intermediate compound of formula (I) with acid to enable optical resolution to isolate the intermediate compound of formula (II) in a stereo-selective manner.