- 专利标题： SALT FORM OF DPPIV INHIBITOR AND PREPARATION METHOD FOR SALT FORM
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申请号： EP17769445.2申请日： 2017-03-22
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公开(公告)号： EP3434678A1公开(公告)日： 2019-01-30
- 发明人: LIU, Hong , WANG, Jiang , LI, Jian , LI, Jia , LI, Jingya , JIANG, Hualiang , LUO, Xiaomin , CHEN, Kaixian
- 申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 申请人地址： 555 Zu Chong Zhi Road Zhangjiang Hi-Tech Park Pudong New District Shanghai 201203 CN
- 专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人地址： 555 Zu Chong Zhi Road Zhangjiang Hi-Tech Park Pudong New District Shanghai 201203 CN
- 代理机构： Mewburn Ellis LLP
- 优先权： CN201610165573 20160322
- 国际公布： WO2017162168 20170928
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; A61K31/519 ; A61P3/10 ; A61P9/12 ; A61P9/10 ; A61P13/12 ; A61P25/00 ; A61P9/00 ; A61P27/02
摘要：
The present invention relates to a salt form of (R)-methyl-2-(3-aminopiperidin-1 -yl)-3-(2-cyanobenzyl)-4-carbonyl-3,4-dihydrothioph ene[3,2-d]pyrimidine-6-carboxylic acid and a preparation method for the salt form. Also disclosed is a pharmaceutical composition of the formula I compound salt form. The salt form of the present invention provides powerful in vivo hypoglycemic activity and is expected to be a novel pharmaceutical active ingredient for treating or preventing diabetes mellitus type 2 and/or complications of diabetes mellitus type 2
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