发明公开
- 专利标题: BRAIN-TARGETING PRODRUG FOR AMPA RECEPTOR SYNERGIST, AND PHARMACEUTICAL APPLICATIONS
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申请号: EP17781872.1申请日: 2017-04-11
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公开(公告)号: EP3444240A1公开(公告)日: 2019-02-20
- 发明人: LI, Song , ZHOU, Xinbo , XIAO, Dian , ZHONG, Wu , XIAO, Junhai , ZHENG, Zhibing , LI, Xingzhou , XIE, Yunde , WANG, Xiaokui
- 申请人: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
- 申请人地址: No. 27 Taiping Road Haidian District Beijing 100850 CN
- 专利权人: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
- 当前专利权人: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
- 当前专利权人地址: No. 27 Taiping Road Haidian District Beijing 100850 CN
- 代理机构: Lavoix
- 优先权: CN201610223637 20160413
- 国际公布: WO2017177896 20171019
- 主分类号: C07D271/12
- IPC分类号: C07D271/12 ; C07D413/12 ; C07H13/04 ; C07H1/00 ; A61K31/4245 ; A61K31/7056 ; A61P25/28 ; A61P25/18 ; A61P25/16 ; A61P25/00 ; A61P11/00
摘要:
Disclosed in the present invention is a compound of Formula (I), a geometric or optical isomer, a pharmaceutically acceptable salt, a solvate or a polymorph thereof. Also disclosed in the present invention is a composition comprising the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof. Also disclosed in the present invention is a use of the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof in the treatment of a disease or disorder such as a hypoglutamatergic condition, a neurodegenerative disease or respiratory depression, particularly in the treatment of a disease or disorder associated with AMPA receptor.
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