发明公开
- 专利标题： SUBSTITUTED PURINE DERIVATIVE
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申请号： EP17789569.5申请日： 2017-04-25
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公开(公告)号： EP3450433A1公开(公告)日： 2019-03-06
- 发明人: TOJO, Shingo , ISOBE, Yoshiaki , IDEUE, Eiji , FUJIWARA, Hiroaki , URABE, Daisuke
- 申请人： Sumitomo Dainippon Pharma Co., Ltd.
- 申请人地址： 6-8, Dosho-machi 2-chome, Chuo-ku, Osaka-shi, Osaka 541-8524 JP
- 专利权人： Sumitomo Dainippon Pharma Co., Ltd.
- 当前专利权人： Sumitomo Dainippon Pharma Co., Ltd.
- 当前专利权人地址： 6-8, Dosho-machi 2-chome, Chuo-ku, Osaka-shi, Osaka 541-8524 JP
- 代理机构： Mewburn Ellis LLP
- 优先权： JP2016087656 20160426
- 国际公布： WO2017188287 20171102
- 主分类号： C07D473/22
- IPC分类号： C07D473/22 ; A61K31/52 ; A61K31/5377 ; A61P37/06 ; A61P43/00 ; C07D487/04 ; C07D519/00
摘要：
The present invention relates to a substituted purine derivative of formula (1) wherein R 1 is alkoxy or the like, R 2 is alkyl or the like, Ring Q 1 is aryl or the like, W 1 is alkylene or the like, Ring Q 2 is aromatic carbocyclyl or the like, n is 1 - 4, R 3 is hydrogen atom or the like, X 1 is single bond or the like, W 2 is alkylene or the like, and R 4 is hydrogen atom or the like, or a pharmaceutically acceptable salt thereof, which has a potent inhibitory effect against TLR7, and thereby is useful for treating autoimmune disease.
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