发明公开
- 专利标题： METHODS FOR PREDICTING THE USEFULNESS OF PROTEINS OR PROTEIN FRAGMENTS FOR IMMUNOTHERAPY
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申请号： EP17726208.6申请日： 2017-05-10
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公开(公告)号： EP3455625A1公开(公告)日： 2019-03-20
- 发明人: VORMEHR, Mathias , SAHIN, Ugur , SCHRÖRS, Barbara , LÖWER, Martin , BOEGEL, Sebastian
- 申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
- 申请人地址： An der Goldgrube 12 55131 Mainz DE
- 专利权人： BioNTech RNA Pharmaceuticals GmbH,TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
- 当前专利权人： BioNTech RNA Pharmaceuticals GmbH,TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
- 当前专利权人地址： An der Goldgrube 12 55131 Mainz DE
- 代理机构： Böhmer, Thomas
- 优先权： PCT/EP2016/060897 20160513
- 国际公布： WO2017194610 20171116
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; G01N33/68 ; G01N33/53
摘要：
The present invention relates to methods for predicting peptides or polypeptides such as T cell epitopes useful for immunotherapy such as for vaccination. In particular, the present invention relates to methods for predicting whether peptides or polypeptides such as tumor-associated antigens or epitopes, in particular tumor-associated neoantigens or neoepitopes, are immunogenic and, in particular, useful for immunotherapy such as for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.
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