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公开(公告)号：EP3792628A3
公开(公告)日：2021-05-19
申请号：EP20193183.9
申请日：2017-05-10
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
摘要： The present invention relates to methods for predicting peptides or polypeptides such as T cell epitopes useful for immunotherapy such as for vaccination. In particular, the present invention relates to methods for predicting whether peptides or polypeptides such as tumor-associated antigens or epitopes, in particular tumor-associated neoantigens or neoepitopes, are immunogenic and, in particular, useful for immunotherapy such as for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.
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2.发明公开
公开(公告)号：EP3455625A1
公开(公告)日：2019-03-20
申请号：EP17726208.6
申请日：2017-05-10
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
摘要： The present invention relates to methods for predicting peptides or polypeptides such as T cell epitopes useful for immunotherapy such as for vaccination. In particular, the present invention relates to methods for predicting whether peptides or polypeptides such as tumor-associated antigens or epitopes, in particular tumor-associated neoantigens or neoepitopes, are immunogenic and, in particular, useful for immunotherapy such as for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.
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公开(公告)号：EP3895727A1
公开(公告)日：2021-10-20
申请号：EP21159558.2
申请日：2014-05-07
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TADMOR, Arbel David , CASTLE, John Christopher , BOEGEL, Sebastian , LÖWER, Martin
摘要： The present invention relates to methods for predicting T cell epitopes. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are immunogenic or not. The methods of the invention are useful, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.
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公开(公告)号：EP3792628A2
公开(公告)日：2021-03-17
申请号：EP20193183.9
申请日：2017-05-10
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
摘要： The present invention relates to methods for predicting peptides or polypeptides such as T cell epitopes useful for immunotherapy such as for vaccination. In particular, the present invention relates to methods for predicting whether peptides or polypeptides such as tumor-associated antigens or epitopes, in particular tumor-associated neoantigens or neoepitopes, are immunogenic and, in particular, useful for immunotherapy such as for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.
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公开(公告)号：EP3455625B1
公开(公告)日：2020-09-02
申请号：EP17726208.6
申请日：2017-05-10
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公开(公告)号：EP2994159A1
公开(公告)日：2016-03-16
申请号：EP14722117.0
申请日：2014-05-07
申请人： BioNTech AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TADMOR, Arbel David , CASTLE, John Christopher , BOEGEL, Sebastian , LÖWER, Martin
CPC分类号： G06F19/18 , A61K39/0011 , C12Q1/6886 , C12Q2600/156
摘要： The present invention relates to methods for predicting T cell epitopes. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are immunogenic or not. The methods of the invention are useful, in particular, for the provision of vaccines which are specific for a patient's tumor and. thus, in the context of personalized cancer vaccines.
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公开(公告)号：EP4411376A2
公开(公告)日：2024-08-07
申请号：EP24171718.0
申请日：2017-05-10
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N33/6878 , G01N33/6887 , G01N2333/471220130101 , G01N2800/5220130101 , G01N33/5035 , A61P35/04
摘要： The present invention relates to methods for predicting peptides or polypeptides such as T cell epitopes useful for immunotherapy such as for vaccination. In particular, the present invention relates to methods for predicting whether peptides or polypeptides such as tumor-associated antigens or epitopes, in particular tumor-associated neoantigens or neoepitopes, are immunogenic and, in particular, useful for immunotherapy such as for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.
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公开(公告)号：EP3256853A1
公开(公告)日：2017-12-20
申请号：EP16704567.3
申请日：2016-02-09
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON-Translationale Onkologie an der Universitätsm Universitätsmedizin der Johannes Gutenberg- Universtität Mainz gGmbH
发明人： SAHIN, Ugur , LÖWER, Martin , TADMOR, Arbel, D. , BOEGEL, Sebastian , SCHRÖRS, Barbara , VORMEHR, Mathias , KREITER, Sebastian
CPC分类号： G01N33/505 , A61K39/0011 , G01N33/6845 , G01N2333/70539 , G01N2500/04
摘要： The present invention relates to methods for predicting T cell epitopes useful for vaccination. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are immunogenic and, in particular, useful for vaccination, or for predicting which of such modifications are most immunogenic and, in particular, most useful for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.
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