- 专利标题： ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY
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申请号： EP18191558.8申请日： 2009-11-18
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公开(公告)号： EP3470437A1公开(公告)日： 2019-04-17
- 发明人: BAROUCH, Dan, H. , KORBER, Bette, T. , FISCHER, William, M.
- 申请人： Beth Israel Deaconess Medical Center , Los Alamos National Security, LLC
- 申请人地址： 330 Brookline Avenue Boston, MA 02215 US
- 专利权人： Beth Israel Deaconess Medical Center,Los Alamos National Security, LLC
- 当前专利权人： Beth Israel Deaconess Medical Center,Los Alamos National Security, LLC
- 当前专利权人地址： 330 Brookline Avenue Boston, MA 02215 US
- 代理机构： Leonard, Thomas Charles
- 优先权： US115703P 20081118; US152184P 20090212; US248188P 20091002
- 主分类号： C07K17/00
- IPC分类号： C07K17/00 ; C07K14/005 ; C12N7/00 ; A61K39/21 ; A61K39/12 ; A61K39/235 ; A61K39/275 ; A61K39/00
摘要：
The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
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