-
公开(公告)号：EP2358757B1
公开(公告)日：2018-09-12
申请号：EP09828172.8
申请日：2009-11-18
IPC分类号： C07K17/00 , C07K14/005 , A61K39/12 , A61K39/235 , A61K39/21 , A61K39/275 , A61K39/00 , C12N7/00
CPC分类号： A61K39/21 , A61K39/12 , A61K39/235 , A61K39/275 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2710/10043 , C12N2710/10343 , C12N2710/24043 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , Y02A50/467
摘要： The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
-
公开(公告)号：EP3470437A1
公开(公告)日：2019-04-17
申请号：EP18191558.8
申请日：2009-11-18
IPC分类号： C07K17/00 , C07K14/005 , C12N7/00 , A61K39/21 , A61K39/12 , A61K39/235 , A61K39/275 , A61K39/00
摘要： The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
-
公开(公告)号：EP2318430A2
公开(公告)日：2011-05-11
申请号：EP09806982.6
申请日：2009-08-14
申请人： Los Alamos National Security, LLC , Beth Israel Deaconess Medical Center , Duke University , The University of Alabama at Birmingham Research Foundation
发明人： KORBER, Bette, T. , FISCHER, William , LETVIN, Norman , LIAO, Hua-xin , HAYNES, Barton, F. , HAHN, Beatrice, H.
IPC分类号： C07K14/155 , C12N15/49 , A61K39/21
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/24143 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334
摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
摘要翻译： 本发明涉及马赛克进化枝M HIV-1 Env多肽和包含其的组合物。 本发明的多肽适用于诱导人体对HIV-1的免疫应答。
-
公开(公告)号：EP1917040A2
公开(公告)日：2008-05-07
申请号：EP06802155.9
申请日：2006-08-23
申请人： The Regents of the University of California , Beth Israel Deaconess Medical Center , Duke University , University of Alabama at Birmingham Research Foundation
发明人： KORBER, Bette, T. , PERKINS, Simon , BHATTACHARYA, Tanmoy , FISCHER, William, M. , THEILER, James , LETVIN, Norman , HAYNES, Barton, F. , HAHN, Beatrice, H. , YUSIM, Karina , KUIKEN, Carla
IPC分类号： A61K48/00
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034
摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
-
5.发明公开ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY 审中-公开ANTIVIRALE IMPFSTOFFE MITERHÖHTERZELLIMMUNOGENITÄT
公开(公告)号：EP2358757A1
公开(公告)日：2011-08-24
申请号：EP09828172.8
申请日：2009-11-18
IPC分类号： C07K17/00
CPC分类号： A61K39/21 , A61K39/12 , A61K39/235 , A61K39/275 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2710/10043 , C12N2710/10343 , C12N2710/24043 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , Y02A50/467
摘要： The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
摘要翻译： 本发明提供用于治疗或预防病毒感染的组合物，方法和试剂盒。 本文所述的多价（例如2价）疫苗引入计算上优化的病毒多肽，其可以增加接种受试者的细胞免疫应答的多样性或广度和深度。
-
6.发明公开COMPOSITIONS COMPRISING CH505 ENVELOPES, AND TRIMERS (EIGHT VALENT HIV-1 COMPOSITION AND METHODS) 审中-公开包含CH505包膜的组合物和修剪物（八价HIV-1组合物和方法）
公开(公告)号：EP3240559A1
公开(公告)日：2017-11-08
申请号：EP15873776.7
申请日：2015-12-23
CPC分类号： C07K14/005 , A61K35/76 , A61K39/12 , A61K2039/545 , A61K2039/55555 , A61K2039/6031 , C12N2740/16122 , C12N2740/16134
摘要： In certain aspects the invention provides a selection of HIV- 1 envelopes suitable for use as immunogens, and methods of using these immunogens in vaccination to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens and methods of using these comprise an immune modulating component.
-
7.发明公开
公开(公告)号：EP3526236A1
公开(公告)日：2019-08-21
申请号：EP17861431.9
申请日：2017-10-17
-
8.发明公开COMPOSITIONS COMPRISING CH848 ENVELOPES AND USES THEREOF 审中-公开ZUSAMMENSETZUNGEN MIT CH848-HÜLLPROTEINENUND VERWENDUNGEN DAVON
公开(公告)号：EP3126502A1
公开(公告)日：2017-02-08
申请号：EP15772335.4
申请日：2015-03-31
申请人： Duke University , The Trustees of The University of Pennsylvania , Los Alamos National Security, LLC
发明人： HAYNES, Barton, F. , HAHN, Beatrice, H. , SHAW, George, M. , KORBER, Bette, T. , HRABER, Peter, T.
IPC分类号： C12N15/49 , C07K14/155 , A61K31/7088 , A61K39/21
CPC分类号： A61K31/7088 , A61K39/12 , A61K39/21 , A61K2039/70 , C07K14/155 , C12N2740/16034
摘要： In certain aspects the invention provides immonogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.
摘要翻译： 在某些方面，本发明提供包含CH848 HIV-1包膜的致突变组合物及其在受试者例如人受试者中诱导免疫应答的方法中的用途。
-
公开(公告)号：EP3423472A1
公开(公告)日：2019-01-09
申请号：EP17760739.7
申请日：2017-03-01
发明人： HAYNES, Barton, F. , BONSIGNORI, Mattia , LIAO, Hua-xin , KORBER, Bette, T. , HRABER, Peter, T. , SAUNDERS, Kevin
IPC分类号： C07K14/155 , C07K14/16
-
公开(公告)号：EP3423091A2
公开(公告)日：2019-01-09
申请号：EP17760960.9
申请日：2017-03-03
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.017 秒)
