- 专利标题: METHOD FOR PRODUCING DIPHENYLMETHANE DERIVATIVE
-
申请号: EP17813615.6申请日: 2017-06-15
-
公开(公告)号: EP3473621A1公开(公告)日: 2019-04-24
- 发明人: YOON, Hee-kyoon , PARK, Se-Hwan , YOON, Ji-sung , CHOI, Soongyu , SEO, Hee Jeong , PARK, Eun-Jung , KONG, Younggyu , SONG, Kwang-Seop , KIM, Min Ju , PARK, So Ok
- 申请人: Daewoong Pharmaceutical Co., Ltd. , Green Cross Corporation
- 申请人地址: 35-14, Jeyakgongdan 4-gil, Hyangnam-eup Hwaseong-si Gyenoggi-do 18623 KR
- 专利权人: Daewoong Pharmaceutical Co., Ltd.,Green Cross Corporation
- 当前专利权人: Daewoong Pharmaceutical Co., Ltd.,Green Cross Corporation
- 当前专利权人地址: 35-14, Jeyakgongdan 4-gil, Hyangnam-eup Hwaseong-si Gyenoggi-do 18623 KR
- 代理机构: dompatent von Kreisler Selting Werner - Partnerschaft von Patent- und Rechtsanwälten mbB
- 优先权: KR20160075910 20160617
- 国际公布: WO2017217792 20171221
- 主分类号: C07D407/04
- IPC分类号: C07D407/04 ; C07D409/04 ; C07D307/78
摘要:
The present invention relates to an improved method for producing a diphenylmethane derivative which is effective as a sodium-dependent glucose cotransporter (SGLT) inhibitor, the method being carried out by means of a convergent synthesis method in which each major group is separately synthesized and then coupled. As such, in comparison to a linear synthesis method disclosed in existing documents, the synthesis pathway is compact and yield can be increased, and risk factors inherent in the linear synthesis pathway can be reduced. Furthermore, the crystal form of the compound produced according to the method has superb physicochemical characteristics, and thus can be effectively utilized in fields such as pharmaceutical manufacturing.
公开/授权文献
- EP3473621B1 METHOD FOR PRODUCING DIPHENYLMETHANE DERIVATIVE 公开/授权日:2021-08-04
信息查询