发明公开
- 专利标题： INJECTABLE PHARMACEUTICAL COMPOSITION OF TECOVIRIMAT AND PREPARATION METHOD THEREOF
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申请号： EP17826908.0申请日： 2017-07-04
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公开(公告)号： EP3485887A1公开(公告)日： 2019-05-22
- 发明人: ZHONG, Wu , YANG, Meiyan , GONG, Wei , WANG, Yuli , GAO, Chunsheng , ZHOU, Xinbo , LI, Song
- 申请人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
- 申请人地址： No. 27 Taiping Road Haidian District Beijing 100850 CN
- 专利权人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
- 当前专利权人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
- 当前专利权人地址： No. 27 Taiping Road Haidian District Beijing 100850 CN
- 代理机构： Lavoix
- 优先权： CN201610559479 20160715
- 国际公布： WO2018010571 20180118
- 主分类号： A61K31/403
- IPC分类号： A61K31/403 ; A61K47/18 ; A61K9/08 ; A61K9/19 ; A61P31/20
摘要：
The present invention relates to a pharmaceutical composition of Tecovirimat for injection, comprising Tecovirimat as an active ingredient, cyclodextrin and an additive. The present invention also relates to a method for preparing the pharmaceutical composition. The composition improves the solubility of Tecovirimat in water by using cyclodextrin and meglumine in combination, as compared with the solubility of Tecovirimat in water by using cyclodextrin or meglumine alone.
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