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1.发明授权JOINT PRODUCT CONTAINING PHENTERMINE AND TOPIRAMATE AND PREPARATION METHOD THEREFOR 有权随着产品芬特明和托吡酯及其制造方法CONNECTION
公开(公告)号：EP2829266B1
公开(公告)日：2016-11-30
申请号：EP13763543.9
申请日：2013-03-20
发明人： LI, Song , GAO, Chunsheng , ZHONG, Wu , WANG, Yuli , YANG, Meiyan , SHAN, Li , ZHOU, Xinbo , ZHENG, Zhibing , WANG, Xiaokui
IPC分类号： A61K9/16 , A61K9/52 , A61K31/35 , A61K31/357 , A61K9/50 , A61K9/48 , A61K31/137
CPC分类号： A61K31/357 , A61K9/4808 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K9/5089 , A61K31/137 , A61K2300/00
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公开(公告)号：EP2829270B1
公开(公告)日：2020-11-11
申请号：EP13764754.1
申请日：2013-03-22
发明人： LI, Song , GAO, Chunsheng , ZHONG, Wu , WANG, Yuli , YANG, Meiyan , SHAN, Li , ZHOU, Xinbo , ZHENG, Zhibing , WANG, Xiaokui
IPC分类号： A61K31/357 , A61K31/137 , A61K9/30 , A61K9/16 , A61P3/04 , A61K9/50
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3.发明授权
公开(公告)号：EP2829267B1
公开(公告)日：2020-05-06
申请号：EP13763714.6
申请日：2013-03-07
发明人： LI, Song , GAO, Chunsheng , ZHONG, Wu , WANG, Yuli , YANG, Meiyan , SHAN, Li , ZHOU, Xinbo , ZHENG, Zhibing , WANG, Xiaokui
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4.发明公开TOPIRAMATE SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION, METHOD FOR PREPARING SAME, AND USE THEREOF 审中-公开制药TOPIRAMATZUSAMMENSETZUNG缓释方法其生产及其用途
公开(公告)号：EP2829267A1
公开(公告)日：2015-01-28
申请号：EP13763714.6
申请日：2013-03-07
发明人： LI, Song , GAO, Chunsheng , ZHONG, Wu , WANG, Yuli , YANG, Meiyan , SHAN, Li , ZHOU, Xinbo , ZHENG, Zhibing , WANG, Xiaokui
IPC分类号： A61K9/22 , A61K31/7048 , A61K47/38 , A61K47/32 , A61P25/06 , A61P25/08 , A61P3/10 , A61P25/00 , A61P25/24 , A61P25/18 , A61P9/12
CPC分类号： A61K31/357 , A61K9/1676 , A61K9/5026 , A61K9/5042 , A61K9/5078 , A61K9/5089 , A61K31/7048
摘要： A sustained-release pharmaceutical composition of topiramate, which is free of binding agent. The sustained-release pharmaceutical composition of topiramate is a sustained-release pellet, comprising a blank pellet core, a drug layer, and a sustained-release coating layer.
摘要翻译： 托吡酯的缓释药物组合物，所有这些都可以自由结合剂。 托吡酯的缓释药物组合物是持续释放球粒，其包含空白丸芯，药物层和缓释包衣层。
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5.发明公开JOINT PRODUCT CONTAINING PHENTERMINE AND TOPIRAMATE AND PREPARATION METHOD THEREFOR 有权含有中间体和TOPIMAMATE的联合产品及其制备方法
公开(公告)号：EP2829266A1
公开(公告)日：2015-01-28
申请号：EP13763543.9
申请日：2013-03-20
发明人： LI, Song , GAO, Chunsheng , ZHONG, Wu , WANG, Yuli , YANG, Meiyan , SHAN, Li , ZHOU, Xinbo , ZHENG, Zhibing , WANG, Xiaokui
IPC分类号： A61K9/16 , A61K9/52 , A61K31/35 , A61K31/357
CPC分类号： A61K31/357 , A61K9/4808 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K9/5089 , A61K31/137 , A61K2300/00
摘要： The present invention provides a combination product, which comprises immediate release pellet of phentermine and sustained-release pellet of topiramate, wherein the pellet of topiramate includes: a) a blank pellet core; b) an active drug layer that contains topiramate and is free of binding agent, the layer being located on surface of the blank pellet core; c) a sustained-release coating layer containing ethyl cellulose and PVP K30, the sustained-release coating layer being located on external of the active drug layer. The present invention further discloses a method for preparing the combination product.
摘要翻译： 本发明提供一种组合产品，其包含苯丁胺和托吡酯缓释小丸的速释小丸，其中托吡酯小丸包括：a）空白小丸芯; b）含有托吡酯且不含结合剂的活性药物层，所述层位于空白丸芯的表面上; c）含有乙基纤维素和PVP K30的缓释包衣层，缓释包衣层位于活性药物层的外部。 本发明还公开了一种制备组合产品的方法。
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公开(公告)号：EP3485886A1
公开(公告)日：2019-05-22
申请号：EP17826907.2
申请日：2017-07-04
发明人： ZHONG, Wu , YANG, Meiyan , GONG, Wei , WANG, Yuli , GAO, Chunsheng , ZHOU, Xinbo , LI, Song
IPC分类号： A61K31/403 , A61K47/18 , A61K9/08 , A61P31/20
摘要： The present invention relates to a pharmaceutical composition, comprising Tecovirimat, cyclodextrin and an additive, and optionally a pharmaceutically acceptable excipient. The present invention also relates to a method for preparing the pharmaceutical composition. The composition improves the solubility of Tecovirimat in water by using cyclodextrin and meglumine in combination, as compared with the solubility of Tecovirimat in water by using cyclodextrin or meglumine alone.
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公开(公告)号：EP3485887A1
公开(公告)日：2019-05-22
申请号：EP17826908.0
申请日：2017-07-04
发明人： ZHONG, Wu , YANG, Meiyan , GONG, Wei , WANG, Yuli , GAO, Chunsheng , ZHOU, Xinbo , LI, Song
IPC分类号： A61K31/403 , A61K47/18 , A61K9/08 , A61K9/19 , A61P31/20
摘要： The present invention relates to a pharmaceutical composition of Tecovirimat for injection, comprising Tecovirimat as an active ingredient, cyclodextrin and an additive. The present invention also relates to a method for preparing the pharmaceutical composition. The composition improves the solubility of Tecovirimat in water by using cyclodextrin and meglumine in combination, as compared with the solubility of Tecovirimat in water by using cyclodextrin or meglumine alone.
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公开(公告)号：EP2829270A1
公开(公告)日：2015-01-28
申请号：EP13764754.1
申请日：2013-03-22
发明人： LI, Song , GAO, Chunsheng , ZHONG, Wu , WANG, Yuli , YANG, Meiyan , SHAN, Li , ZHOU, Xinbo , ZHENG, Zhibing , WANG, Xiaokui
IPC分类号： A61K31/357 , A61K31/137 , A61K9/30 , A61K9/16 , A61P3/04
摘要： The present invention provides a joint product comprising synephrine and topiramate, in which the synephrine or salt thereof is administered in form of rapid-release preparation, preferably rapid-release pellet, having daily dose of 2mg to 25mg, preferably 5mg to 20mg; the topiramate is administered in form of sustained-release or controlled-release preparation, preferably sustained-release pellet, having daily dose of 20mg to 100mg, preferably 23mg to 92mg. The composition is used for treatment of obesity or other diseases associated with obesity.
摘要翻译： 本发明提供了含有辛弗林和托吡酯的联合产品，其中辛弗林或其盐以快速释放制剂形式给药，优选快速释放小丸，其日剂量为2mg至25mg，优选5mg至20mg; 托吡酯以缓释或控释制剂的形式给药，优选缓释小丸，其每日剂量为20mg至100mg，优选23mg至92mg。 该组合物用于治疗肥胖或其他与肥胖有关的疾病。
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