- 专利标题： ENZYMES AND METHODS FOR CLEAVING N-GLYCANS FROM GLYCOPROTEINS
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申请号： EP19151657.4申请日： 2013-02-14
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公开(公告)号： EP3502123A1公开(公告)日： 2019-06-26
- 发明人: GARRIDO, Daniel , GERMAN, J. Bruce , LEBRILLA, Carlito B. , MILLS, David A.
- 申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 申请人地址： 1111 Franklin Street, 12th Floor Oakland, CA 94607-5200 US
- 专利权人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 当前专利权人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 当前专利权人地址： 1111 Franklin Street, 12th Floor Oakland, CA 94607-5200 US
- 代理机构： J A Kemp
- 优先权： US201261598593P 20120214
- 主分类号： C07K7/06
- IPC分类号： C07K7/06 ; A61K38/08 ; C12N15/52 ; A61P37/00
摘要：
Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
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