- 专利标题： ANTI-PD-1/ANTI-HER2 NATURAL ANTIBODY STRUCTURE-LIKE BISPECIFIC ANTIBODY OF HETERODIMERIC FORM AND PREPARATION THEREOF
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申请号： EP17871719.5申请日： 2017-11-16
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公开(公告)号： EP3533804A1公开(公告)日： 2019-09-04
- 发明人: LIU, Jiawang , SONG, Nanmeng , YANG, Yaping , KIM, Maengsup
- 申请人： Beijing Hanmi Pharmaceutical Co., Ltd.
- 申请人地址： No.10 Tianzhu West Road Tianzhu Airport Industrial Zone A Shunyi District Beijing 101312 CN
- 专利权人： Beijing Hanmi Pharmaceutical Co., Ltd.
- 当前专利权人： Beijing Hanmi Pharmaceutical Co., Ltd.
- 当前专利权人地址： No.10 Tianzhu West Road Tianzhu Airport Industrial Zone A Shunyi District Beijing 101312 CN
- 代理机构： Brevalex
- 优先权： CN201611016435 20161118
- 国际公布： WO2018090950 20180524
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; C07K16/46 ; C07K16/28 ; A61K39/395 ; A61P35/00
摘要：
Provided are an anti-PD-1/anti-HER2 natural antibody structural heterodimeric bispecific antibody and a method of preparing the same. Specifically, provided are a highly stable anti-PD-1/anti-HER2 heterodimeric bispecific antibody having characteristics of a natural IgG and having no mismatched heavy chain and light chain, and a method of preparing the same. The bispecific antibody may bind to both of two kinds of target molecules, and thus may be more effective in treating complex diseases.
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