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1.发明公开N-BENZOATE GROUP SUBSTITUTED BENZOPYRROLINE-2-ONE DERIVATIVE AND USE THEREOF 审中-公开N-苯甲酸酯基团取代的苯并吡咯啉-2-酮衍生物及其用途
公开(公告)号：EP3252038A1
公开(公告)日：2017-12-06
申请号：EP16742703.8
申请日：2016-01-22
发明人： XUE, Hai , ZHAO, Tao , CHA, Mi Young , KIM, Maengsup
IPC分类号： C07D209/08 , C07D209/10 , A61K31/404 , A61P29/00
CPC分类号： A61K31/404 , A61K31/03 , A61K31/192 , A61K31/196 , C07D209/08 , C07D209/10 , Y02A50/409
摘要： Disclosed are a compound, a stereisomer and a tautomer thereof, a pharmaceutically acceptable salt thereof, and a solvate or a prodrug thereof, which can be used for preventing or treating a RORγ mediated disease. The compound has the structural formula (I).
摘要翻译： 本发明公开了可用于预防或治疗RORγ介导的疾病的化合物，立体异构体及其互变异构体，其药学上可接受的盐及其溶剂化物或前药。 该化合物具有结构式（I）。
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2.发明公开COMPOUND INHIBITING ACTIVITIES OF BTK AND/OR JAK3 KINASES 审中-公开VERBINDUNG ZUR HEMMUNG VONAKTIVITÄTENVON BTK- UND / ODER JAK3-KINASEN
公开(公告)号：EP3048105A1
公开(公告)日：2016-07-27
申请号：EP14846251.8
申请日：2014-09-18
发明人： LIU, Jinming , CHA, Mi Young , LI, Gong , LI, Zhanmei , QIU, Hongjuan , KIM, Maengsup
IPC分类号： C07D487/04 , C07D491/048 , C07D495/04 , C07D519/00 , A61K31/53 , A61K31/519 , A61K31/5377 , A61P37/02 , A61P29/00 , A61P7/02 , A61P35/00 , A61P19/02 , A61P11/00 , A61P17/06 , A61P1/00
CPC分类号： C07D495/04 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D487/04 , C07D491/048 , C07D519/00 , A61K2300/00
摘要： The present invention relates to a compound inhibiting the activities of Bruton's tyrosine kinase (BTK) and/or Janus kinase 3 (JAK3), a pharmaceutical composition of the compound, pharmaceutical applications of same, a method for using the compound in inhibiting the activities of BTK and/or JAK3, and a method for using the compound in treatment and/or prevention of BTK- and/or JAK3-mediated diseases or disorders in mammals (especially human). The compound is as represented by structural formula ( I ).
摘要翻译： 本发明涉及抑制Bruton酪氨酸激酶（BTK）和/或Janus激酶3（JAK3）的活性的化合物，该化合物的药物组合物，其药物应用，使用该化合物抑制活性的方法 BTK和/或JAK3，以及在哺乳动物（特别是人）中用于治疗和/或预防BTK和/或JAK3介导的疾病或病症的方法。 该化合物由结构式（I）表示。
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3.发明公开
公开(公告)号：EP3878870A1
公开(公告)日：2021-09-15
申请号：EP19881762.9
申请日：2019-11-05
发明人： LIU, Jiawang , YANG, Yaping , SONG, Nanmeng , XIAO, Wenchu , CHUNG, Chulwoong , KIM, Maengsup
IPC分类号： C07K16/28 , C07K16/24 , C07K16/32 , C07K16/46 , C07K14/54 , C12N15/13 , A61K47/68 , A61K39/395
摘要： Provided are an anti-TNFa/anti IL-17A natural antibody structure-like heterodimer form of a bispecific antibody and a preparation methodtherefor, wherein the antibody can bind two target molecules simultaneously, and can be used for treating complex diseases.
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公开(公告)号：EP3336090A1
公开(公告)日：2018-06-20
申请号：EP16834688.0
申请日：2016-08-12
发明人： XU, Jiangcheng , CAI, Qingyuan , CHA, Mi Young , KIM, Maengsup
IPC分类号： C07D487/04 , A61K31/4162 , A61P29/00
摘要： Disclosed are a compound related to inhibiting the activity of an IRAK4 kinase, a pharmaceutical composition thereof, a use thereof in preparing drugs, a method in which same is used for inhibiting the activity of the IRAK4 kinase and a method in which same is used for treating and/or preventing IRAK4 kinase mediated diseases or conditions in mammals (especially humans). The compound has a structural formula I.
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5.发明公开
公开(公告)号：EP3533804A1
公开(公告)日：2019-09-04
申请号：EP17871719.5
申请日：2017-11-16
发明人： LIU, Jiawang , SONG, Nanmeng , YANG, Yaping , KIM, Maengsup
IPC分类号： C07K16/30 , C07K16/46 , C07K16/28 , A61K39/395 , A61P35/00
摘要： Provided are an anti-PD-1/anti-HER2 natural antibody structural heterodimeric bispecific antibody and a method of preparing the same. Specifically, provided are a highly stable anti-PD-1/anti-HER2 heterodimeric bispecific antibody having characteristics of a natural IgG and having no mismatched heavy chain and light chain, and a method of preparing the same. The bispecific antibody may bind to both of two kinds of target molecules, and thus may be more effective in treating complex diseases.
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公开(公告)号：EP3504234A1
公开(公告)日：2019-07-03
申请号：EP17854952.3
申请日：2017-09-28
发明人： LIU, Jiawang , SONG, Nanmeng , YANG, Dongge , YANG, Yaping , KIM, Maengsup
IPC分类号： C07K16/00 , A61K39/395 , C12N15/13 , A61P37/02 , A61P35/00
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公开(公告)号：EP3336091A1
公开(公告)日：2018-06-20
申请号：EP15900787.1
申请日：2015-08-13
发明人： XUE, Baoyu , ZHENG, Runa , CHA, Mi Young , KIM, Maengsup
IPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61P7/02 , A61P1/04 , A61P19/02 , A61P35/00 , A61P37/00
CPC分类号： A61K31/519 , A61K31/5377 , C07D495/04
摘要： The present invention relates to a compound inhibiting the activity of an IRAK4 kinase, a pharmaceutical composition thereof, a use thereof in preparing drugs, a method in which same is used for inhibiting the activity of the IRAK4 kinase and a method in which same is used for treating and/or preventing IRAK4 kinase mediated diseases or conditions in mammals (particularly humans). The compound has a structural formula I .
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公开(公告)号：EP3336091B1
公开(公告)日：2020-12-02
申请号：EP15900787.1
申请日：2015-08-13
发明人： XUE, Baoyu , ZHENG, Runa , CHA, Mi Young , KIM, Maengsup
IPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61P7/02 , A61P1/04 , A61P19/02 , A61P35/00 , A61P37/00
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公开(公告)号：EP3336090B1
公开(公告)日：2020-07-22
申请号：EP16834688.0
申请日：2016-08-12
发明人： XU, Jiangcheng , CAI, Qingyuan , CHA, Mi Young , KIM, Maengsup
IPC分类号： C07D487/04 , A61K31/4162 , A61P29/00
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公开(公告)号：EP3252038B1
公开(公告)日：2020-04-08
申请号：EP16742703.8
申请日：2016-01-22
发明人： XUE, Hai , ZHAO, Tao , CHA, Mi Young , KIM, Maengsup
IPC分类号： C07D209/08 , C07D209/10 , A61K31/404 , A61P29/00
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