- 专利标题： METHODS FOR ACHIEVING THERAPEUTICALLY EFFECTIVE DOSES OF ANTI-CD47 AGENTS
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申请号： EP19166334.3申请日： 2014-02-26
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公开(公告)号： EP3536709A1公开(公告)日： 2019-09-11
- 发明人: WILLINGHAM, Stephen , HOWARD, Maureen , LIU, Jie , MAJETI, Ravindra , PROHASKA, Susan Sweeney , VOLKMER, Anne K. , VOLKMER, Jens-Peter , WEISSMAN, Irving L.
- 申请人： The Board of Trustees of The Leland Stanford Junior University
- 申请人地址： Office of The General Counsel Building 170, 3rd Floor, Main Quad P.O. Box 20386 Stanford, CA 94305-2038 US
- 专利权人： The Board of Trustees of The Leland Stanford Junior University
- 当前专利权人： The Board of Trustees of The Leland Stanford Junior University
- 当前专利权人地址： Office of The General Counsel Building 170, 3rd Floor, Main Quad P.O. Box 20386 Stanford, CA 94305-2038 US
- 代理机构： Chapman, Desmond Mark
- 优先权： US201361800102P 20130315
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K38/18
摘要：
Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject. Turnover of cells begins with the induction of an apoptotic program or other cellular changes that mark them for removal, and the subsequent recognition of markers by phagocytes, including macrophages, dendritic cells, and the like. This process requires a specific and selective removal of unwanted cells.
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