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1.发明公开
公开(公告)号：EP2970493A1
公开(公告)日：2016-01-20
申请号：EP14768797.4
申请日：2014-02-26
发明人： WILLINGHAM, Stephen , HOWARD, Maureen , LIU, Jie , MAJETI, Ravindra , PROHASKA, Susan , VOLKMER, Anne K. , VOLKMER, Jens-Peter , WEISSMAN, Irving L.
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , A61K38/1774 , A61K38/1816 , A61K39/3955 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K16/2896 , C07K2317/24 , C07K2317/33 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , Y02A50/403 , Y02A50/41 , Y02A50/412 , A61K2300/00
摘要： Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.
摘要翻译： 提供了通过在向受试者施用治疗有效剂量的抗CD47剂之前施用引物剂来用治疗剂量的抗CD47剂治疗受试者的方法。 细胞的转换始于诱导凋亡程序或其他细胞变化，标记它们的去除，以及随后由吞噬细胞（包括巨噬细胞，树突细胞等）识别标记。 这个过程需要特定的和有选择的去除不需要的细胞。
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公开(公告)号：EP3536709A1
公开(公告)日：2019-09-11
申请号：EP19166334.3
申请日：2014-02-26
发明人： WILLINGHAM, Stephen , HOWARD, Maureen , LIU, Jie , MAJETI, Ravindra , PROHASKA, Susan Sweeney , VOLKMER, Anne K. , VOLKMER, Jens-Peter , WEISSMAN, Irving L.
摘要： Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject. Turnover of cells begins with the induction of an apoptotic program or other cellular changes that mark them for removal, and the subsequent recognition of markers by phagocytes, including macrophages, dendritic cells, and the like. This process requires a specific and selective removal of unwanted cells.
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公开(公告)号：EP2970493B1
公开(公告)日：2019-04-03
申请号：EP14768797.4
申请日：2014-02-26
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公开(公告)号：EP3792285A1
公开(公告)日：2021-03-17
申请号：EP20201319.9
申请日：2014-02-26
发明人： WILLINGHAM, Stephen , HOWARD, Maureen , LIU, Jie , MAJETI, Ravindra , PROHASKA, Susan Sweeney , VOLKMER, Anne K. , VOLKMER, Jens-Peter , WEISSMAN, Irving L.
IPC分类号： C07K16/28 , A61K38/18 , A61P43/00 , A61K39/395 , A61K38/17 , A61P35/00 , A61P35/02 , A61P31/00 , A61K39/00
摘要： Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject. Turnover of cells begins with the induction of an apoptotic program or other cellular changes that mark them for removal, and the subsequent recognition of markers by phagocytes, including macrophages, dendritic cells, and the like. This process requires a specific and selective removal of unwanted cells.
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