- 专利标题： BENZYLISOQUINOLINE ALKALOIDS (BIA) PRODUCING MICROBES, AND METHODS OF MAKING AND USING THE SAME
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申请号： EP19156536.5申请日： 2014-03-14
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公开(公告)号： EP3553177A1公开(公告)日： 2019-10-16
- 发明人: SMOKE, Christina, D. , THODEY, Catherine , TRENCHARD, Isis , GALANIE, Stephanie
- 申请人： The Board of Trustees of the Leland Stanford Junior University
- 申请人地址： Office of the General Counsel Building 170, Third Floor, Main Quad P.O. Box 20386 Stanford, CA 94305-2038 US
- 专利权人： The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人： The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人地址： Office of the General Counsel Building 170, Third Floor, Main Quad P.O. Box 20386 Stanford, CA 94305-2038 US
- 代理机构： Avidity IP
- 优先权： US201361788560P 20130315
- 主分类号： C12N15/82
- IPC分类号： C12N15/82 ; C12N1/16
摘要：
Aspects of the invention include host cells that are engineered to produce benzylisoquinoline alkaloids (BIAs). The host cells include heterologous coding sequences for a variety of enzymes involved in synthetic pathways from starting compounds to BIAs of the host cell. Also provided are methods of producing the BIAs of interest by culturing the host cells under culture conditions that promote expression of enzymes encoded by the heterologous coding sequences of the host cells. Aspects of the invention further include compositions, e.g., host cells, starting compounds and kits, etc., that find use in methods of the invention.
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