- 专利标题： CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
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申请号： EP19174765.8申请日： 2014-03-14
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公开(公告)号： EP3590922A1公开(公告)日： 2020-01-08
- 发明人: WINTERS, Geoffrey C. , MANDEL, Alexander Laurence , RICH, James R , HEDBERG, Bradley John , HSIEH, Tom Han Hsiao , BOURQUE, Elyse Marie Josée , BABCOOK, John
- 申请人： Zymeworks Inc.
- 申请人地址： 540-1385 West 8th Avenue Vancouver, British Colombia V6H 3V9 CA
- 专利权人： Zymeworks Inc.
- 当前专利权人： Zymeworks Inc.
- 当前专利权人地址： 540-1385 West 8th Avenue Vancouver, British Colombia V6H 3V9 CA
- 代理机构： Secerna LLP
- 优先权： US201361792020P 20130315; US201361792066P 20130315
- 主分类号： C07D207/08
- IPC分类号： C07D207/08 ; C07D207/452 ; C07D211/34 ; C07D211/60 ; C07D213/56 ; C07D213/71 ; C07D333/34 ; C07C311/51 ; C07C323/12 ; C07C323/67 ; C07C327/06 ; C07C381/08 ; A61K38/05 ; A61K38/06 ; A61P35/00
摘要：
Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
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