公开(公告)号：EP4482819A2

公开(公告)日：2025-01-01

申请号：EP23712728.7

申请日：2023-02-23

Applicant: Vivasor, Inc.

Inventor： WANG, Peng ,  WANG, Hua ,  SUN, Haotian ,  ZENG, Ying ,  XIE, Hui

IPC: C07C219/06 ,  C07C323/12 ,  C07C323/41 ,  C07C335/08 ,  C07D317/24 ,  C07D317/28 ,  A61K9/00 ,  A61K47/00

公开(公告)号：EP4244204A1

公开(公告)日：2023-09-20

申请号：EP21843801.8

申请日：2021-11-12

Applicant: META PLATFORMS TECHNOLOGIES, LLC

Inventor： PURVIS, Lafe Joseph, II ,  LANE, Austin ,  COLBURN, Matthew E.

IPC: C07C271/16 ,  C07C271/28 ,  C07C271/48 ,  C07C323/12 ,  C07C323/20 ,  C07C323/43 ,  C07C333/04 ,  C07D317/64 ,  G03F7/00 ,  G03H1/02

公开(公告)号：EP4198018A1

公开(公告)日：2023-06-21

申请号：EP21214445.5

申请日：2021-12-14

Applicant: Henkel AG & Co. KGaA

Inventor： Ito, Kenji ,  Taden, Andreas ,  Beck, Horst ,  Brandt, Adrian ,  de Vries, Johannes Gerardus ,  Mazloomi, Zahra

IPC: C07C323/12 ,  C07C43/215 ,  C08F2/00

Abstract: The present application is directed to a polythiol compound obtainable independently from a) eugenol, b) gallic acid, c) the adduct of guaiacol and vanillin ord) resveratrol and, respectively, having the general Formula VIA, VIB, VIC or VID, wherein: R 1 is a C 1 -C 18 alkylene group, C 2 -C 18 oxyalkylene group, C 2 -C 18 thioalkylene group, C 6 -C 18 arylene or C 7 -C 18 aralkylene group; and R 2 is H or methyl.

公开(公告)号：EP4122920A1

公开(公告)日：2023-01-25

申请号：EP22184814.6

申请日：2022-07-13

Applicant: Suzhou Curemed Biomedical Technology Co. Ltd

Inventor： HUANG, Ke ,  GE, Binxi ,  LI, Yingwen ,  LIU, Yuping ,  GAO, Yinjia ,  SUN, Zhenhua

IPC: C07D233/60 ,  C07C229/00 ,  C07C321/00 ,  C07C217/08 ,  C07C229/16 ,  C07C323/12 ,  C07C323/25 ,  C07C323/52 ,  A61K9/51 ,  A61K48/00

Abstract: The present invention belongs to the technical field of gene therapy, and particularly relates to a series of lipid compounds as well as a lipid carrier, nucleic acid lipid nanoparticle composition and pharmaceutical preparation containing the same. A compound having a structure of a formula (I) provided by the present invention can be used for preparing a lipid carrier together with other lipid compounds, and exhibits pH response, and the entrapment efficiency to a nucleic acid drug is high, which greatly improves in-vivo delivery efficiency of the nucleic acid drug; and furthermore, a lipid compound with a specific structure can be chosen as a lipid carrier based on an organ in which the nucleic acid drug needs to be enriched, having a good market application prospect.

公开(公告)号：EP3932383B1

公开(公告)日：2022-08-24

申请号：EP20184024.6

申请日：2020-07-03

Inventor： MOSZNER, Norbert ,  CATEL, Yohann ,  LAMPARTH, Iris

IPC: A61K6/889 ,  C07C271/00 ,  C07C321/12 ,  C07C323/12 ,  A61K6/62 ,  A61K6/818 ,  A61K6/833

公开(公告)号：EP3956334A1

公开(公告)日：2022-02-23

申请号：EP20718675.0

申请日：2020-04-17

Applicant: Merck Patent GmbH

Inventor： GERSTENECKER, Stefan

IPC: C07F7/18 ,  C07D309/10 ,  C07C69/54 ,  C07C69/653 ,  C07C255/47 ,  C07C255/54 ,  C07C309/65 ,  C07C309/67 ,  C07C317/18 ,  C07C323/12 ,  C07C323/18 ,  C07C323/65 ,  C07C327/28 ,  B29D11/00 ,  C08F220/24 ,  C08F224/00

公开(公告)号：EP3883923A1

公开(公告)日：2021-09-29

申请号：EP19805317.5

申请日：2019-11-21

Applicant: Evonik Operations GmbH

Inventor： HIEROLD, Judith ,  KOPP, Andrea ,  RAUTENBERG, Stephan ,  RENNER, Christian

IPC: C07C319/12 ,  C07C323/12

公开(公告)号：EP3041577B1

公开(公告)日：2021-07-21

申请号：EP14841451.9

申请日：2014-09-05

Inventor： WITTKOWSKI, Knut, M.

IPC: A61K31/196 ,  A61K31/44 ,  A61K31/197 ,  A61K31/195 ,  A61K47/55 ,  A61P25/28 ,  A61P25/00 ,  A61K45/06 ,  C07C323/12

公开(公告)号：EP3284772B8

公开(公告)日：2019-10-16

申请号：EP17181770.3

申请日：2009-03-30

Applicant: PRC-DESOTO INTERNATIONAL, INC.

Inventor： GILMORE, John, R. ,  RAO, Chandra B.

IPC: C08G75/04 ,  B64G1/00 ,  C07C321/00 ,  C07C323/12 ,  C09D181/02 ,  C08G75/02 ,  C08G75/0259 ,  B64G1/22 ,  C08L63/00

公开(公告)号：EP3424903A1

公开(公告)日：2019-01-09

申请号：EP17759944.6

申请日：2017-02-28

Applicant: Kumiai Chemical Industry Co., Ltd.

Inventor： YASUMURA, Shingo

IPC: C07C319/20 ,  C07C315/02 ,  C07C317/22 ,  C07C323/12 ,  B01J31/22 ,  C07B61/00

Abstract: [Problem]
To provide an industrially preferred method for producing a sulfoxide derivative.
[Solution]
A method for producing a sulfoxide derivative represented by general formula (1),

the method being characterized in that a sulfide derivative represented by general formula (2)

is reacted with an oxidizing agent in the presence of a catalyst that is a metal-ligand complex containing a metal compound and, as a ligand, a compound represented by general formula (3),

and in the presence of a benzoic acid compound represented by general formula (4).

Selected drawing: None