- 专利标题： STABILIZATION OF POLY(A) SEQUENCE ENCODING DNA SEQUENCES
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申请号： EP19180818.7申请日： 2015-07-06
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公开(公告)号： EP3594337A1公开(公告)日： 2020-01-15
- 发明人: EBERLE, Florian , SAHIN, Ugur , KUHN, Andreas , VALLAZZA, Britta , DIKEN, Mustafa
- 申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
- 申请人地址： An der Goldgrube 12 55131 Mainz DE
- 专利权人： BioNTech RNA Pharmaceuticals GmbH,TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
- 当前专利权人： BioNTech RNA Pharmaceuticals GmbH,TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
- 当前专利权人地址： An der Goldgrube 12 55131 Mainz DE
- 代理机构： Böhmer, Thomas
- 优先权： PCT/EP2014/064924 20140711
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; C12N15/67 ; C12N15/68
摘要：
The present invention relates to nucleic acid molecules containing poly(dA:dT) regions which are stabilized in E.coli, methods of propagating such nucleic acid molecules in E.coli, methods of obtaining RNA, peptides or proteins using such nucleic acid molecules and to RNA which is obtained from such nucleic acid molecules and its use. In particular, the poly(dA:dT) regions contain at least one disruption by a sequence not encoding a sequence solely composed of A residues.
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