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公开(公告)号：EP3594337A1
公开(公告)日：2020-01-15
申请号：EP19180818.7
申请日：2015-07-06
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
摘要： The present invention relates to nucleic acid molecules containing poly(dA:dT) regions which are stabilized in E.coli, methods of propagating such nucleic acid molecules in E.coli, methods of obtaining RNA, peptides or proteins using such nucleic acid molecules and to RNA which is obtained from such nucleic acid molecules and its use. In particular, the poly(dA:dT) regions contain at least one disruption by a sequence not encoding a sequence solely composed of A residues.
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公开(公告)号：EP3167059A1
公开(公告)日：2017-05-17
申请号：EP15738014.8
申请日：2015-07-06
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
CPC分类号： C12N15/68 , A61K39/00 , A61K48/0066 , A61K2039/53 , C12N15/67 , C12N15/70 , C12N15/85 , C12N2830/50 , C12P19/34 , C12P21/00
摘要： The present invention relates to nucleic acid molecules containing poly (dA:dT) regions which are stabilized in E. coli, methods of propagating such nucleic acid molecules in E. coli, methods of obtaining RNA, peptides or proteins using such nucleic acid molecules and to RNA which is obtained from such nucleic acid molecules and its use. In particular, the poly (dA:dT) regions contain at least one disruption by a sequence not encoding a sequence solely composed of A residues.
摘要翻译： 本发明涉及包含在大肠杆菌中稳定的聚（dA：dT）区域的核酸分子，在大肠杆菌中繁殖所述核酸分子的方法，使用这种核酸分子获得RNA，肽或蛋白质的方法和 涉及从这样的核酸分子获得的RNA及其用途。 具体而言，聚（dA：dT）区域通过不编码仅由A残基组成的序列的序列包含至少一个破坏。
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公开(公告)号：EP3167059B1
公开(公告)日：2019-06-26
申请号：EP15738014.8
申请日：2015-07-06
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