- 专利标题： ANTIBODIES TO PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) AND USES THEREOF
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申请号： EP19201382.9申请日： 2014-08-13
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公开(公告)号： EP3620472A1公开(公告)日： 2020-03-11
- 发明人: PRITSKER, Alla , GRAILHE, Patrick , RAK, Alexey , MATHIEU, Magali , MORGAN, Christopher Ryan , BAURIN, Nicolas , POIRIER, Bruno , DAVEU, Cyril , DUFFIEUX, Francis , LI, Han , KOMINOS, Dorothea , JANIAK, Philip
- 申请人： Sanofi
- 申请人地址： 54, rue La Boétie 75008 Paris FR
- 专利权人： Sanofi
- 当前专利权人： Sanofi
- 当前专利权人地址： 54, rue La Boétie 75008 Paris FR
- 代理机构： Lavoix
- 优先权： US201361865451P 20130813; EP14305757 20140522
- 主分类号： C07K16/38
- IPC分类号： C07K16/38
摘要：
The invention provides antibodies that specifically bind to Plasminogen Activator Inhibitor type-1 (PAI-1). The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-PAI-1 antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies to modulate PAI-1 activity or detect PAI-1, either in vitro or in vivo, are also provided. The disclosure further provides methods of making antibodies that specifically bind to PAI-1 in the active conformational state.
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