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    ANTIBODIES TO PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) AND USES THEREOF
    3.
    发明公开
    ANTIBODIES TO PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) AND USES THEREOF 审中-公开
    ANTIKÖRPERGEGEN DEN PLASMINOGEN-AKTIVATOR-HEMMER 1（PAI-1）UND VERWENDUNGEN DAVON

    公开(公告)号：EP3033359A1

    公开(公告)日：2016-06-22

    申请号：EP14761451.5

    申请日：2014-08-13

    申请人： SANOFI

    发明人： PRITSKER, Alla ,  GRAILHE, Patrick ,  RAK, Alexey ,  MATHIEU, Magali ,  MORGAN, Christopher Ryan ,  BAURIN, Nicolas ,  POIRIER, Bruno ,  DAVEU, Cyril ,  DUFFIEUX, Francis ,  LI, Han ,  KOMINOS, Dorothea ,  JANIAK, Philip

    IPC分类号： C07K16/38

    摘要： The invention provides antibodies that specifically bind to Plasminogen Activator inhibitor type-1 (PAI-1), The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-PAI-1 antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies to modulate PAI-1 activity or detect PAI-1, either in vitro or in vivo, are also provided. The disclosure further provides methods of making antibodies that specifically bind to PAI-1 in the active conformational state.

    摘要翻译： 本发明提供了特异性结合纤溶酶原激活物抑制剂1型（PAI-1）的抗体。本发明还提供了药物组合物，以及编码抗PAI-1抗体的核酸，用于制备这种抗体的重组表达载体和宿主细胞 ，或其片段。 还提供了在体外或体内使用抗体调节PAI-1活性或检测PAI-1的方法。 本公开进一步提供了制备特异性结合活性构象状态的PAI-1的抗体的方法。

    ANTI-CEACAM5 ANTIBODIES AND USES THEREOF
    6.
    发明公开
    ANTI-CEACAM5 ANTIBODIES AND USES THEREOF 审中-公开
    抗CEACAM5抗体及其用途

    公开(公告)号：EP3199552A1

    公开(公告)日：2017-08-02

    申请号：EP17157890.9

    申请日：2013-11-20

    申请人： SANOFI

    发明人： BERNE, Pierre-François ,  BLANCHE, Francis ,  BOUCHARD, Hervé ,  CAMERON, Béatrice ,  DABDOUBI, Tarik ,  DECARY, Stéphanie ,  FERRARI, Paul ,  RAK, Alexey

    IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00

    摘要： The present disclosure describes antibodies which bind human and Macaca fascicularis CEACAM5 proteins, as well as isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibodies. The disclosure also provides immunoconjugates comprising said antibodies conjugated or linked to a growth-inhibitory agent, and to pharmaceutical compositions comprising antibodies, or immunoconjugates of the disclosure . The antibodies or immunoconjugates of the disclosure are used for the treatment of cancer or for diagnostic purposes.

    摘要翻译： 本公开描述了结合人和食蟹猴CEACAM5蛋白的抗体，以及包含编码所述抗体的序列的分离的核酸，载体和宿主细胞。 本公开还提供了包含与生长抑制剂缀合或连接的所述抗体的免疫缀合物，并且涉及包含抗体的药物组合物或本公开的免疫缀合物。 本公开的抗体或免疫偶联物用于治疗癌症或用于诊断目的。