- 专利标题： mu-OPIOID RECEPTOR AGONIST AND PREPARATION METHOD THEREFOR AND USE THEREOF IN FIELD OF MEDICINE
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申请号： EP18857198.8申请日： 2018-09-17
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公开(公告)号： EP3686198A1公开(公告)日： 2020-07-29
- 发明人: XU, Xin , ZHANG, Zhen , LI, Yunfei , ZHANG, Liming , GUO, Fengying , JIANG, Qingyun , LI, Dongsheng , ZHANG, Linli , SONG, Jinqian , LIU, Lei , LIU, Qiang , SU, Jing , WANG, Yijin , GE, Jian
- 申请人： Shanghai Synergy Pharmaceutical Sciences Co., Ltd , Zhejiang Huahai Pharmaceutical Co., Ltd
- 申请人地址： Zhangheng Rd 1999 Zhangjiang Hi-Tech Park Pudong New District Shanghai 201203 CN
- 专利权人： Shanghai Synergy Pharmaceutical Sciences Co., Ltd,Zhejiang Huahai Pharmaceutical Co., Ltd
- 当前专利权人： Shanghai Synergy Pharmaceutical Sciences Co., Ltd,Zhejiang Huahai Pharmaceutical Co., Ltd
- 当前专利权人地址： Zhangheng Rd 1999 Zhangjiang Hi-Tech Park Pudong New District Shanghai 201203 CN
- 代理机构： Engelhard, Markus
- 优先权： CN201710840488 20170918
- 国际公布： WO2019052557 20190321
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; C07D405/14 ; C07D405/04 ; A61K31/444 ; A61K31/4433 ; A61P29/00
摘要：
Disclosed are a class of µ-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The µ-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.
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