公开(公告)号：EP3686198A1

公开(公告)日：2020-07-29

申请号：EP18857198.8

申请日：2018-09-17

申请人： Shanghai Synergy Pharmaceutical Sciences Co., Ltd ,  Zhejiang Huahai Pharmaceutical Co., Ltd

发明人： XU, Xin ,  ZHANG, Zhen ,  LI, Yunfei ,  ZHANG, Liming ,  GUO, Fengying ,  JIANG, Qingyun ,  LI, Dongsheng ,  ZHANG, Linli ,  SONG, Jinqian ,  LIU, Lei ,  LIU, Qiang ,  SU, Jing ,  WANG, Yijin ,  GE, Jian

IPC分类号： C07D405/12 ,  C07D405/14 ,  C07D405/04 ,  A61K31/444 ,  A61K31/4433 ,  A61P29/00

摘要： Disclosed are a class of µ-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The µ-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.

公开(公告)号：EP3438099A1

公开(公告)日：2019-02-06

申请号：EP17773210.4

申请日：2017-03-28

申请人： Shanghai Synergy Pharmaceutical Sciences Co., Ltd

发明人： GE, Jian ,  LI, Yunfei ,  WANG, Jiamiao ,  WANG, Yijin ,  XIA, Xiaoer ,  XU, Xin ,  ZHANG, Zhen ,  LIU, Lei ,  ZHANG, Xiaojuan ,  ZHANG, Liming ,  LI, Dongsheng

IPC分类号： C07D295/096 ,  C07C65/11 ,  C07C51/41 ,  A61K31/495 ,  A61P25/24 ,  A61P25/30 ,  A61P25/32 ,  A61P25/28 ,  A61P25/04 ,  A61P25/00 ,  A61P29/00

摘要： The present application provides a vortioxetine pamoic acid salt, which includes a crystal form, a solvate or an amorphous substance of the vortioxetine pamoic acid salt. The present application provides a preparation method and use of the vortioxetine pamoic acid salt and the crystal form thereof. The vortioxetine pamoic acid salt prepared in the present application prolongs the residence time of the vortioxetine in vivo, achieving a slow release of the vortioxetine in vivo, and is suitable for preparing a long-acting dosage form.