- 专利标题： GENETICALLY ENGINEERED GAMMA DELTA T CELL
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申请号： EP18877609.0申请日： 2018-11-13
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公开(公告)号： EP3712260A1公开(公告)日： 2020-09-23
- 发明人: LI, Yi , ZHOU, Peipei
- 申请人： Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences
- 申请人地址： 190 Kai Yuan Avenue Science Park Guangzhou, Guangdong 510530 CN
- 专利权人： Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences
- 当前专利权人： Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences
- 当前专利权人地址： 190 Kai Yuan Avenue Science Park Guangzhou, Guangdong 510530 CN
- 代理机构： Mewburn Ellis LLP
- 优先权： CN201711124057 20171114
- 国际公布： WO2019096127 20190523
- 主分类号： C12N5/22
- IPC分类号： C12N5/22 ; A61K39/00 ; A61P31/00 ; A61P35/00
摘要：
Provided is a genetically engineered γδT cell, which is characterized in that a high-affinity αβTCR gene is transferred into the γδT cell, and the affinity of the high-affinity αβTCR to the specific pMHC thereof is at least two times of that of a wild-type αβTCR corresponding thereto. Further provided are a use of and a preparation method for the γδT cell.
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