- 专利标题: METHOD FOR CONJUGATING ANTIBODY AND PHYSIOLOGICALLY ACTIVE SUBSTANCE
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申请号: EP18882347.0申请日: 2018-11-29
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公开(公告)号: EP3719031A2公开(公告)日: 2020-10-07
- 发明人: YOO, Tae Hyeon , PARK, Jisoo , LEE, Yumi
- 申请人: Ajou University Industry-Academic Cooperation Foundation and Technology
- 申请人地址: 206, World Cup-ro Yeongtong-gu Suwon-si, Gyeonggi-do 16499 KR
- 专利权人: Ajou University Industry-Academic Cooperation Foundation and Technology
- 当前专利权人: Ajou University Industry-Academic Cooperation Foundation and Technology
- 当前专利权人地址: 206, World Cup-ro Yeongtong-gu Suwon-si, Gyeonggi-do 16499 KR
- 代理机构: Mewburn Ellis LLP
- 优先权: KR20170161452 20171129; KR20180146289 20181123
- 国际公布: WO2019107962 20190606
- 主分类号: C07K7/08
- IPC分类号: C07K7/08 ; A61K47/64 ; A61K47/65 ; A61K47/68
摘要:
The present invention relates to an antibody conjugating peptide including an amino acid having a photoreactive functional group, a physiologically active substance modified with the conjugating peptide, and an antibody conjugate having an antibody linked to the physiologically active substance. When the physiologically active substance modified with the conjugating peptide according to the present invention is linked to the antibody, the conjugation efficiency between the antibody and the physiologically active substance is remarkably improved as compared to that of the conventional art, and thus, the drug may be firmly bound without impairing the specificity of the antibody, thereby making it possible to accelerate commercialization of the antibody conjugate.
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