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    COMPOSITION CONTAININGPERILLA FRUTESCENS
    1.
    发明公开
    COMPOSITION CONTAININGPERILLA FRUTESCENS 审中-公开

    公开(公告)号：EP3718554A1

    公开(公告)日：2020-10-07

    申请号：EP18882507.9

    申请日：2018-11-23

    申请人： Ajou University Industry-Academic Cooperation Foundation and Technology

    发明人： JUNG, Yi Sook ,  KIM, Tae Ho

    IPC分类号： A61K36/535 ,  A23L33/105

    摘要： The present invention relates to a pharmaceutical composition or health functional food composition comprising a Perilla frutescens fermented extract for prevention or treatment of a sleep disorder. In addition, the present invention relates to a composition or a fiber or fragrance composition comprising a Perilla frutescens fermented extract for sleep improvement. In addition, the present invention relates to a method for treatment of a sleep disorder, the method comprising a step of administering a Perilla frutescens fermented extract to a patient with a sleep disorder. In addition, the present invention relates to a use of a Perilla frutescens fermented extract for use in the preparation of a composition for treatment of a sleep disorder or for prevention or treatment of a sleep disorder. Therefore, in the present invention, the Perilla frutescens fermented extract, compared with an unfermented Perilla frutescens extract, significantly shortens sleep latency and significantly increases total sleeping time, and thus the Perilla frutescens fermented extract is effective as a composition for prevention, alleviation, or treatment of a sleep disorder or for sleep improvement, and can be also effectively used in a treatment method for a sleep disorder.

    METHOD FOR CONJUGATING ANTIBODY AND PHYSIOLOGICALLY ACTIVE SUBSTANCE
    7.
    发明公开
    METHOD FOR CONJUGATING ANTIBODY AND PHYSIOLOGICALLY ACTIVE SUBSTANCE 审中-公开

    公开(公告)号：EP3719031A2

    公开(公告)日：2020-10-07

    申请号：EP18882347.0

    申请日：2018-11-29

    申请人： Ajou University Industry-Academic Cooperation Foundation and Technology

    发明人： YOO, Tae Hyeon ,  PARK, Jisoo ,  LEE, Yumi

    IPC分类号： C07K7/08 ,  A61K47/64 ,  A61K47/65 ,  A61K47/68

    摘要： The present invention relates to an antibody conjugating peptide including an amino acid having a photoreactive functional group, a physiologically active substance modified with the conjugating peptide, and an antibody conjugate having an antibody linked to the physiologically active substance. When the physiologically active substance modified with the conjugating peptide according to the present invention is linked to the antibody, the conjugation efficiency between the antibody and the physiologically active substance is remarkably improved as compared to that of the conventional art, and thus, the drug may be firmly bound without impairing the specificity of the antibody, thereby making it possible to accelerate commercialization of the antibody conjugate.

    MICROSURGICAL INSTRUMENT CAPABLE OF JOINT MOTION AND ROTATIONAL MOTION
    8.
    发明公开
    MICROSURGICAL INSTRUMENT CAPABLE OF JOINT MOTION AND ROTATIONAL MOTION 审中-公开

    公开(公告)号：EP3636163A1

    公开(公告)日：2020-04-15

    申请号：EP18794619.9

    申请日：2018-05-03

    申请人： Ajou University Industry-Academic Cooperation Foundation and Technology

    发明人： ROH, Tae Hoon

    IPC分类号： A61B17/00

    摘要： The present disclosure provides a fine surgical instrument capable of performing a joint movement and a rotational movement. The fine surgical instrument includes a rod portion (100, 100', 100") which is formed in a longitudinal direction to enter a surgery site located in a narrow space, a joint portion (200, 200', 200") which is formed on one side of the rod portion (100, 100', 100") and rotates in one direction from the one side of the rod portion (100, 100', 100"), a shaft (300) which is inserted into the rod portion (100, 100', 100"), a handle portion (400) which is coupled with the other side of the rod portion (100, 100', 100"), and a distal end portion (500) which is coupled with one end of the shaft (300) and is connected to the handle portion (400), in which the distal end portion (500) is operated along a manipulation of the handle portion (400).