- 专利标题： TETRAHYDRO-PYRIDO[3,4-B]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
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申请号： EP20184866.0申请日： 2015-12-17
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公开(公告)号： EP3760623A1公开(公告)日： 2021-01-06
- 发明人: GOODACRE, Simon Charles , LABADIE, Sharada , LIANG, Jun , ORTWINE, Daniel Fred , RAY, Nicholas Charles , WANG, Xiaojing , ZBIEG, Jason , ZHANG, Birong
- 申请人： F. Hoffmann-La Roche AG
- 申请人地址： CH 4070 Basel Grenzacherstrasse 124
- 代理机构： Neuhaus, Christian Michel
- 优先权： US201562142077 P 20150402
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; A61K31/397 ; A61K31/4025 ; C07D403/02 ; C07D403/14 ; C07D409/02 ; C07D413/02 ; C07D417/02 ; C07D417/14 ; C07D205/04 ; C07D207/08 ; C07D493/04 ; C07D411/02 ; A61P35/00
摘要：
Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure:
and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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