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公开(公告)号：EP3760623A1
公开(公告)日：2021-01-06
申请号：EP20184866.0
申请日：2015-12-17
发明人： GOODACRE, Simon Charles , LABADIE, Sharada , LIANG, Jun , ORTWINE, Daniel Fred , RAY, Nicholas Charles , WANG, Xiaojing , ZBIEG, Jason , ZHANG, Birong
IPC分类号： C07D401/14 , A61K31/397 , A61K31/4025 , C07D403/02 , C07D403/14 , C07D409/02 , C07D413/02 , C07D417/02 , C07D417/14 , C07D205/04 , C07D207/08 , C07D493/04 , C07D411/02 , A61P35/00
摘要： Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure:
and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.-
公开(公告)号：EP3233852B1
公开(公告)日：2020-07-15
申请号：EP15810660.9
申请日：2015-12-17
发明人： GOODACRE, Simon Charles , LABADIE, Sharada , LIANG, Jun , ORTWINE, Daniel Fred , RAY, Nicholas Charles , WANG, Xiaojing , ZBIEG, Jason , ZHANG, Birong , LAI, Kwong Wah , LIAO, Jiangpeng , LIU, Zhiguo , WAI, John Sui-Man , WANG, Tao , LI, Jun
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
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公开(公告)号：EP3535255A1
公开(公告)日：2019-09-11
申请号：EP17792068.3
申请日：2017-10-31
发明人： BRONNER, Sarah M. , CRAWFORD, James J. , CRIDLAND, Andrew , CYR, Patrick , FAUBER, Benjamin , GANCIA, Emanuela , GOBBI, Alberto , HURLEY, Christopher , KILLEN, Jonathan , LEE, Wendy , RENE, Olivier , VAN NIEL, Monique Bodil , WARD, Stuart , WINSHIP, Paul , ZBIEG, Jason
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D403/14 , C07D409/14 , A61K31/502 , A61P17/06 , A61P37/00
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公开(公告)号：EP3472159A1
公开(公告)日：2019-04-24
申请号：EP17730168.6
申请日：2017-06-15
发明人： GOODACRE, Simon Charles , LABADIE, Sharada , LI, Jun , LIANG, Jun , LIU, Zhiguo , ORTWINE, Daniel Fred , RAY, Nicholas Charles , WANG, Tao , WANG, Xiaojing , ZBIEG, Jason , ZHANG, Birong
IPC分类号： C07D471/04 , A61K31/4375
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公开(公告)号：EP3374356A1
公开(公告)日：2018-09-19
申请号：EP16791412.6
申请日：2016-11-08
发明人： LIANG, Jun , ORTWINE, Daniel Fred , WANG, Xiaojing , ZBIEG, Jason
IPC分类号： C07D405/12 , C07D205/04 , C07D207/06 , A61K31/397 , A61K31/401
CPC分类号： C07D205/04 , A61K31/397 , A61K31/40 , A61K45/06 , C07D207/06 , C07D401/12 , C07D405/12
摘要： Described herein are tetrahydronaphthalene compounds with estrogen receptor modulation activity or function having the Formula (I) structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula (I) compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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6.发明公开TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF 审中-公开四氢吡啶并[3,4-b]吲哚雌激素受体调节剂及其应用
公开(公告)号：EP3233852A1
公开(公告)日：2017-10-25
申请号：EP15810660.9
申请日：2015-12-17
发明人： GOODACRE, Simon Charles , LABADIE, Sharada , LIANG, Jun , ORTWINE, Daniel Fred , RAY, Nicholas Charles , WANG, Xiaojing , ZBIEG, Jason , ZHANG, Birong
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
摘要翻译： 本文描述了具有式（I）结构的雌激素受体调节活性或功能的四氢吡啶并[3,4-b]吲哚-1-基化合物及其立体异构体，互变异构体或药学上可接受的盐，并且具有取代基和结构 在此描述的特征。 还描述了包含式（I）化合物的药物组合物和药物，以及单独使用这种雌激素受体调节剂并与其他治疗剂组合使用以治疗介导或依赖于雌激素受体的疾病或病症的方法。
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公开(公告)号：EP3472162A1
公开(公告)日：2019-04-24
申请号：EP17733754.0
申请日：2017-06-15
发明人： GOODACRE, Simon Charles , LABADIE, Sharada , LI, Jun , LIANG, Jun , LIAO, Jiangpeng , ORTWINE, Daniel Fred , RAY, Nicholas Charles , WANG, Xiaojing , ZBIEG, Jason , ZHANG, Birong
IPC分类号： C07D471/04 , C07D471/14 , C07D471/20 , C07D487/04 , C07D491/04 , C07D495/04 , A61K31/7056 , A61P35/00
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公开(公告)号：EP3440067A1
公开(公告)日：2019-02-13
申请号：EP17715939.9
申请日：2017-04-07
发明人： LABADIE, Sharada , LIANG, Jun , ORTWINE, Daniel Fred , WANG, Xiaojing , ZHANG, Birong , ZBIEG, Jason , VINOGRADOVA, Maia , WANG, Tao
IPC分类号： C07D401/12 , C07D403/12 , C07D401/14 , C07D471/04 , A61P35/00 , A61K31/4725 , A61K31/4745
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9.发明公开
公开(公告)号：EP3233818A1
公开(公告)日：2017-10-25
申请号：EP15821037.7
申请日：2015-12-17
发明人： GOVEK, Steven P. , KAHRAMAN, Mehmet , LABADIE, Sharada , LI, Jun , LIANG, Jun , NAGASAWA, Johnny Y. , ORTWINE, Daniel Fred , SMITH, Nicholas D. , WANG, Xiaojing , ZBIEG, Jason
IPC分类号： C07D311/14 , A61K31/352 , A61P35/00
CPC分类号： A61K31/4025 , A61K31/397 , A61K31/404 , A61K31/4184 , A61K45/06 , C07D311/14 , C07D401/12 , C07D401/14
摘要： Described herein are compounds that are estrogen receptor modulators of Formula I and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
摘要翻译： 本文描述了式I的雌激素受体调节剂及其立体异构体，互变异构体或药学上可接受的盐以及本文所述的取代基和结构特征的化合物。 还描述了包含本文所述化合物的药物组合物和药物，以及单独使用此类雌激素受体调节剂并与其他化合物一起使用以治疗介导或依赖于雌激素受体的疾病或病症的方法。
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