- 专利标题: CRYSTAL OF COMPOUND AS C-MET KINASE INHIBITOR AND PREPARATION METHOD THEREFOR AND USE THEREOF
-
申请号: EP19761595.8申请日: 2019-03-01
-
公开(公告)号: EP3766870A1公开(公告)日: 2021-01-20
- 发明人: GONG, Feng , HUANG, Ticong , ZANG, Haishan , ZHANG, Shibo , ZHAO, Rui , LIU, Fei
- 申请人: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. , Advenchen Laboratories Nanjing Ltd.
- 申请人地址: CN Lianyungang, Jiangsu 222062 No. 369 Yuzhou South Road; CN Nanjing, Jiangsu 210061 Room 302, Block A, Pharmaceutical & Biology Incubator Building Entrepreneurship Center Nanjing New & High Tech Zone
- 代理机构: Bianchetti Bracco Minoja S.r.l.
- 优先权: CN201810174767 20180302
- 国际公布: WO2019166012 20190906
- 主分类号: C07D215/22
- IPC分类号: C07D215/22 ; A61K31/47 ; A61P35/00 ; A61P29/00 ; A61P37/06
摘要:
The present application falls within the field of medicinal chemistry, relates to the crystalline of a compound as a c-Met kinase inhibitor, and specifically relates to the crystalline of N-(4-((7-((1-(cyclopentylamino)cyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and a preparation method therefor, a crystalline composition thereof, and a pharmaceutical composition thereof, as well as the use of the crystalline for treating diseases associated with the inhibition of growth factor receptor protein tyrosine kinase activity. The crystalline of the present application has excellent properties in at least one of the following aspects: pharmacokinetics, bioavailability, hygroscopicity, stability, solubility, purity, ease of preparation, etc.
公开/授权文献
信息查询