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1.发明公开
公开(公告)号：EP3766870A1
公开(公告)日：2021-01-20
申请号：EP19761595.8
申请日：2019-03-01
发明人： GONG, Feng , HUANG, Ticong , ZANG, Haishan , ZHANG, Shibo , ZHAO, Rui , LIU, Fei
IPC分类号： C07D215/22 , A61K31/47 , A61P35/00 , A61P29/00 , A61P37/06
摘要： The present application falls within the field of medicinal chemistry, relates to the crystalline of a compound as a c-Met kinase inhibitor, and specifically relates to the crystalline of N-(4-((7-((1-(cyclopentylamino)cyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and a preparation method therefor, a crystalline composition thereof, and a pharmaceutical composition thereof, as well as the use of the crystalline for treating diseases associated with the inhibition of growth factor receptor protein tyrosine kinase activity. The crystalline of the present application has excellent properties in at least one of the following aspects: pharmacokinetics, bioavailability, hygroscopicity, stability, solubility, purity, ease of preparation, etc.
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2.发明公开
公开(公告)号：EP4279138A3
公开(公告)日：2024-03-27
申请号：EP23198543.3
申请日：2019-03-01
发明人： GONG, Feng , HUANG, Ticong , ZANG, Haishan , ZHANG, Shibo , ZHAO, Rui , LIU, Fei
IPC分类号： C07D215/22 , A61K31/47 , A61P35/00
摘要： The present application falls within the field of medicinal chemistry, relates to the crystal of a compound as a c-Met kinase inhibitor, and specifically relates to the crystal of N-(4-((7-((1-(cyclopentylamino)cyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-3-fl uorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and a preparation method therefor, a crystalline composition thereof, and a pharmaceutical composition thereof, as well as the use of the crystal for treating diseases associated with the inhibition of growth factor receptor protein tyrosine kinase activity. The crystal of the present application has excellent properties in at least one of the following aspects: pharmacokinetics, bioavailability, hygroscopicity, stability, solubility, purity, ease of preparation, etc.
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3.发明公开
公开(公告)号：EP4279138A2
公开(公告)日：2023-11-22
申请号：EP23198543.3
申请日：2019-03-01
发明人： GONG, Feng , HUANG, Ticong , ZANG, Haishan , ZHANG, Shibo , ZHAO, Rui , LIU, Fei
IPC分类号： A61P35/00
摘要： The present application falls within the field of medicinal chemistry, relates to the crystal of a compound as a c-Met kinase inhibitor, and specifically relates to the crystal of N-(4-((7-((1-(cyclopentylamino)cyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-3-fl uorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and a preparation method therefor, a crystalline composition thereof, and a pharmaceutical composition thereof, as well as the use of the crystal for treating diseases associated with the inhibition of growth factor receptor protein tyrosine kinase activity. The crystal of the present application has excellent properties in at least one of the following aspects: pharmacokinetics, bioavailability, hygroscopicity, stability, solubility, purity, ease of preparation, etc.
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