- 专利标题： THERAPEUTIC DRUG FOR DISEASES RELATED TO ENDOPLASMIC RETICULUM CELL DEATH IN CORNEAL ENDOTHELIUM
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申请号： EP20195546.5申请日： 2014-10-30
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公开(公告)号： EP3804760A1公开(公告)日： 2021-04-14
- 发明人: KOIZUMI, Noriko , OKUMURA, Naoki , KINOSHITA, Shigeru
- 申请人： Kyoto Prefectural Public University Corporation , The Doshisha , Senju Pharmaceutical Co., Ltd.
- 申请人地址： JP Kyoto-shi, Kyoto 602-8566 465 Kajii-cho Hirokoji-agaru Kawaramachi-dori Kamigyo-ku; JP Kyoto-shi, Kyoto 602-8580 601 Gembu-cho Karasuma-Higashi-iru Imadegawa-dori Kamigyo-ku; JP Osaka-shi, Osaka 541-0048 3-1-9, Kawara-machi, Chuo-ku,
- 代理机构： Engelhard, Markus
- 优先权： JP2014184172 20140910
- 主分类号： A61K45/00
- IPC分类号： A61K45/00 ; A61K31/437 ; A61K31/4439 ; A61K31/444 ; A61K31/4709 ; A61K31/519 ; A61K31/713 ; A61K48/00 ; A61P27/02 ; A61P43/00 ; A61K38/00 ; A61K39/395 ; A61K9/00 ; C07K16/22 ; A61P3/00 ; A61P29/00
摘要：
The present invention provides a treatment drug or prophylactic drug for diseases, disorders, or conditions related to endoplasmic reticulum (ER) stress. Specifically, the present invention provides a treatment drug or prophylactic drug for diseases, disorders, or conditions related to endoplasmic reticulum (ER) stress in the corneal epithelium, the drug containing a TGFβ-signal inhibitor. As a preferred TGFβ-signal inhibitor, the drug contains 4-[4-(1,3-benzodioxole-5-yl)-5-(2-pyridinyl)-1H-imidazole-2-yl]benzamide.
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