A method of creating a virtual model of a normal anatomy of a pathological knee joint, the method comprising: obtaining a virtual model of a subject knee joint generated from fluoroscopic images of the subject knee joint, the subject knee joint comprising a distal portion of a femur and a proximal portion of a tibia, the subject knee joint exhibiting at least one pathology; determining a plurality of contact regions between the femur and the tibia at a plurality of positions of the subject knee joint; determining a plurality of normal cartilage thicknesses at the plurality of contact regions; determining a plurality of cartilage losses at the plurality of contact regions for each of the plurality of positions of the subject knee joint; and generating a virtual model of a normal anatomy of the subject knee joint by realigning the femur and the tibia of the virtual model of the subject knee joint to correct for the plurality of cartilage losses.