- 专利标题： LIGAND-DRUG CONJUGATE OF EXATECAN ANALOGUE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
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申请号： EP19866595.2申请日： 2019-09-25
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公开(公告)号： EP3858386A1公开(公告)日： 2021-08-04
- 发明人: XU, Jianyan , ZHANG, Ying , CAI, Xiaofeng , QU, Bolei , LIANG, Jindong , ZHANG, Lianshan , HE, Feng , TAO, Weikang
- 申请人： Jiangsu Hengrui Medicine Co., Ltd. , Shanghai Hengrui Pharmaceutical Co., Ltd.
- 申请人地址： CN Lianyungang, Jiangsu 222047 No. 7 Kunlunshan Road Economic and Technological Development Zone; CN Shanghai 200245 No.279 Wenjing Road Minhang District
- 代理机构： Potter Clarkson
- 优先权： CN201811123833 20180926
- 国际公布： WO2020063676 20200402
- 主分类号： A61K47/68
- IPC分类号： A61K47/68 ; A61K47/65 ; A61K47/54 ; A61K38/07 ; A61P35/00 ; A61P37/02
摘要：
The present invention relates to a ligand-drug conjugate of an exatecan analogue, a preparation method therefor and an application thereof. Specifically, the present invention provides a ligand-drug conjugate having a structure shown in formula (-D), a preparation method therefor, a pharmaceutical composition containing same, and use thereof in preparation of drugs for treating cancers by means of receptor regulation. The definition of each substituent in formula (-D) is the same as that in the description.
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