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1.发明公开
公开(公告)号：EP3858386A1
公开(公告)日：2021-08-04
申请号：EP19866595.2
申请日：2019-09-25
发明人： XU, Jianyan , ZHANG, Ying , CAI, Xiaofeng , QU, Bolei , LIANG, Jindong , ZHANG, Lianshan , HE, Feng , TAO, Weikang
摘要： The present invention relates to a ligand-drug conjugate of an exatecan analogue, a preparation method therefor and an application thereof. Specifically, the present invention provides a ligand-drug conjugate having a structure shown in formula (-D), a preparation method therefor, a pharmaceutical composition containing same, and use thereof in preparation of drugs for treating cancers by means of receptor regulation. The definition of each substituent in formula (-D) is the same as that in the description.
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公开(公告)号：EP3421463A1
公开(公告)日：2019-01-02
申请号：EP17755844.2
申请日：2017-02-24
发明人： XU, Jianyan , ZHANG, Ying , QU, Bolei , JIANG, Guiyang
IPC分类号： C07D403/12 , C07D209/02
摘要： The present invention relates to a new toxin and a method for preparing an intermediate thereof. In particular, the present invention relates to a new toxin and a method for preparating intermediates (III) and (IV) thereof, and a preparation method for synthesizing what is shown in general formula (I). The method comprises subjecting a chiral compound shown in general formula (III) to a series of protective group addition, protective group removal and amidation so as to obtain a compound as shown in general formula(I). The present method has the advantages of mild reaction condition, simple operation, high optical purity and high synthetic yield, and is suitable for large-scale production.
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3.发明公开ANTI-C-MET ANTIBODY AND ANTI-C-MET ANTIBODY-CYTOTOXIC DRUG CONJUGATE AND PHARMACEUTICAL USE THEREOF 审中-公开抗C-MET抗体和抗C-MET抗体 - 细胞毒药物偶联物及其药物用途
公开(公告)号：EP3284751A1
公开(公告)日：2018-02-21
申请号：EP16779555.8
申请日：2016-04-07
申请人： Suzhou Suncadia Biopharmaceuticals Co., Ltd. , Jiangsu Hengrui Medicine Co., Ltd. , Shanghai Hengrui Pharmaceutical Co., Ltd.
发明人： LIU, Jiajian , ZHANG, Lianshan , TAO, Weikang , FU, Yayuan , ZHANG, Ling , MA, Dong , CUI, Dongbing , WANG, Yali , XU, Jianyan , LIANG, Jindong , ZHANG, Ying , JIANG, Guiyang , QIU, Junzhuan , SUN, Ziyong , ZHA, Jiping , WEI, Jingping
IPC分类号： C07K16/28 , C12N15/13 , C12N15/63 , C12N5/10 , C12P21/02 , A61K39/395 , A61K47/48 , A61K45/00 , A61K31/4745 , A61K31/537 , A61K38/08 , A61K38/06
CPC分类号： A61K47/6849 , A61K31/4745 , A61K31/537 , A61K38/00 , A61K38/08 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6863 , A61K47/6889 , A61K2039/505 , A61P35/00 , C07K16/2863 , C07K16/30 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/464 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/77 , C07K2317/94 , C12N2510/00 , C12P21/02
摘要： Provided are an anti-c-Met antibody or antigen binding fragment, and an anti-c-Met antibody-cytotoxic drug conjugate, wherein the antibody or antigen binding fragment is a chimeric antibody or a humanized antibody. Also provided are a pharmaceutical composition containing a humanized anti-c-Met antibody or antigen binding fragment, antibody-cytotoxic drug conjugate, or a pharmaceutically acceptable salt or solvent compound thereof, applied in the treatment of cancer.
摘要翻译： 提供了抗c-Met抗体或抗原结合片段和抗c-Met抗体 - 细胞毒性药物缀合物，其中所述抗体或抗原结合片段是嵌合抗体或人源化抗体。 还提供了包含用于治疗癌症的人源化抗c-Met抗体或抗原结合片段，抗体 - 细胞毒性药物缀合物或其药学上可接受的盐或溶剂化合物的药物组合物。
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4.发明公开LIGAND-CYTOTOXICITY DRUG CONJUGATE, PREPARING METHOD THEREFOR, AND APPLICATION THEREOF 审中-公开配体 - 细胞毒药物共轭物及其制备方法及其应用
公开(公告)号：EP3251698A1
公开(公告)日：2017-12-06
申请号：EP16748591.1
申请日：2016-01-26
发明人： XU, Jianyan , ZHANG, Ying , QU, Bolei , ZHANG, Fuyao , YU, Xiuzhao , LIANG, Jindong , JIANG, Guiyang , ZHANG, Lianshan , LI, Ang , WANG, Yali
CPC分类号： A61K47/6889 , A61K47/50 , A61K47/6817 , A61K47/6849 , A61K47/6855 , A61K47/6857 , A61K47/6863 , A61P35/00 , C07K7/06 , C07K16/2863 , C07K16/30 , C07K16/3023 , C07K16/32 , C07K2317/56 , C07K2317/73 , C07K2317/76 , Y02P20/55
摘要： Provide are a ligand-cytotoxicity drug conjugate with a general formula of PC-L-Dr, a preparing method thereof, and applications of the ligand-cytotoxicity drug conjugate and pharmaceutical compositions comprising the same in preparing drugs for treating cancers by means of receptor regulation.
摘要翻译： 提供具有通式PC-L-Dr的配体 - 细胞毒性药物缀合物及其制备方法，以及配体 - 细胞毒性药物缀合物和包含其的药物组合物在通过受体调节来制备用于治疗癌症的药物中的应用 。
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公开(公告)号：EP3854816A1
公开(公告)日：2021-07-28
申请号：EP19865297.6
申请日：2019-09-25
发明人： YING, Hua , ZHANG, Ling , ZHANG, Ting , ZHANG, Lei , XU, Jianyan , TAO, Weikang
IPC分类号： C07K16/28 , A61K39/395 , A61K31/4745 , A61K31/48 , A61P35/00
摘要： Disclosed by the present invention are an anti-B7H3 antibody-exatecan analog conjugate, a preparation method therefor and an anti-tumor medicinal use thereof.
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公开(公告)号：EP4410307A1
公开(公告)日：2024-08-07
申请号：EP22875194.7
申请日：2022-09-30
申请人： Jiangsu Hengrui Pharmaceuticals Co., Ltd. , Shanghai Hengrui Pharmaceutical Co., Ltd. , Suncadia Pharmaceuticals Co., Ltd
发明人： XU, Jianyan , CAI, Xiaofeng , QU, Bolei , ZHANG, Ying , CHEN, Xiaoxi , HE, Feng , TAO, Weikang , ZHU, Lingjian , HONG, Min , HUANG, Jian , LI, Yanbing , XU, Xiaolang , HU, Zhipeng , XUE, Zhouyang , YOU, Lingfeng
CPC分类号： A61K47/68 , A61P35/00 , A61K47/68035 , A61K47/6851 , A61K47/6855 , C07K16/28 , C07K16/32
摘要： The present disclosure relates to a pyrrolo benzodiazepine derivative and a conjugate, preparation method and use thereof. In particular, the present disclosure relates to a compound of formula (DL) and a antibody-drug conjugate thereof, a pharmaceutical composition containing same, and a use thereof in the preparation of a medicament for the treatment of cancer. The definitions of groups in the general formula (DL) are as defined in the description.
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7.发明公开
公开(公告)号：EP4180422A1
公开(公告)日：2023-05-17
申请号：EP21837191.2
申请日：2021-07-09
发明人： XU, Jianyan , GAO, Jianhong , ZHANG, Ying , HE, Feng , TAO, Weikang
IPC分类号： C07D211/34 , C07D401/12 , A61K31/451 , A61K31/454 , A61P35/00
摘要： Provided are a sulfonylbenzamide derivative and a conjugate thereof, a preparation method therefor, and the use thereof. In particular, provided is a sulfonylbenzamide derivative having a structure as represented by formula (D), a conjugate thereof, a preparation method therefor, a pharmaceutical composition containing same, and the use thereof in the preparation of a drug for treating cancers by means of receptor regulation. Each substituent in general formula (D) is as defined in the description.
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公开(公告)号：EP4074345A1
公开(公告)日：2022-10-19
申请号：EP20898395.7
申请日：2020-12-11
发明人： YANG, Yang , XU, Jianyan , TAO, Weikang
IPC分类号： A61K47/68 , A61K39/395 , A61K31/4745 , A61P35/00
摘要： An anti-claudin antibody-drug conjugate and a pharmaceutical use thereof, specifically relating to a ligand-drug conjugate represented by general formula (Pc-L-Y-D), wherein Pc is an anti-claudin 18.2 antibody or an antigen-binding fragment thereof, and L, Y, and n are as defined in the description.
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