- 专利标题： 3,4-DIHYDRO-2H-SPIRO[ISOQUINOLINE-1,4'-PIPERIDIN]AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
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申请号： EP20382069.1申请日： 2020-02-03
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公开(公告)号： EP3858438A1公开(公告)日： 2021-08-04
- 发明人: ALMANSA-ROSALES, Carmen , OSORIO-PLANES, Laura
- 申请人： ESTEVE PHARMACEUTICALS, S.A.
- 申请人地址： ES 08038 Barcelona Passeig de la Zona Franca, 109, 4ª Planta
- 主分类号： A61P25/04
- IPC分类号： A61P25/04 ; A61K31/435 ; C07D471/10
摘要：
The present invention relates to new compounds that show pharmacological activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels or dual activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels, and the µ-opiod receptor (MOR or mu-opioid). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
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