专利检索 ap:"ESTEVE PHARMACEUTICALS, S.A." 第 1 页

1.

发明公开
OXADIAZASPIRO COMPOUNDS FOR USE IN THE TREATMENT OF MOTONEURON DEGENERATION OR IN NEUROPROTECTION 审中-实审

公开(公告)号：EP4404933A1

公开(公告)日：2024-07-31

申请号：EP22790466.1

申请日：2022-09-16

申请人： ESTEVE PHARMACEUTICALS, S.A.

发明人： VELA-HERNANDEZ, Jose-Miguel , MERLOS-ROCA, Manuel , NAVARRO-ACEBES, Xavier , HERRANDO-GRABULOSA, Mireia

IPC分类号： A61K31/5375 , A61K31/5386 , A61P21/00 , A61P25/28

CPC分类号： A61K31/5375 , A61K31/5386 , A61P25/28 , A61P21/00

2.

发明公开
PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN 审中-公开

公开(公告)号：EP4157843A1

公开(公告)日：2023-04-05

申请号：EP21726917.4

申请日：2021-05-20

申请人： ESTEVE PHARMACEUTICALS, S.A.

发明人： FERNANDEZ-DONIS, Ariadna , DÍAZ-FERNÁNDEZ, José-Luís , ALMANSA-ROSALES, Carmen , GARCIA-LOPEZ, Mónica , FERNANDEZ-COLLADO, Joan-Carles , GONZALEZ-GARCIA, Jordi , GARRIDO-MARTINEZ, Maria

IPC分类号： C07D487/04 , A61P29/02 , A61K31/519

3.

发明公开
HOMOPIPERAZINYL AND HOMOPIPERIDINYL QUINAZOLIN-4(3H)-ONE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN 审中-公开

公开(公告)号：EP4041391A1

公开(公告)日：2022-08-17

申请号：EP20790213.1

申请日：2020-10-05

申请人： ESTEVE PHARMACEUTICALS, S.A.

发明人： ALMANSA-ROSALES, Carmen , FERNANDEZ-DONIS, Ariadna , DÍAZ-FERNÁNDEZ, José-Luís , GARCIA-LOPEZ, Mónica , RODRIGUEZ-ESCRICH, Sergi , CHRISTMANN, Ute

IPC分类号： A61P25/04 , C07D403/06 , C07D471/04 , C07D401/14 , C07D405/14 , C07D471/08

4.

发明公开
ALKYLAMINOPROLINE DERIVATIVES AS ALFA-2-DELTA-1 BLOCKERS 审中-公开

公开(公告)号：EP3904339A1

公开(公告)日：2021-11-03

申请号：EP20382342.2

申请日：2020-04-28

申请人： ESTEVE PHARMACEUTICALS, S.A.

发明人： WEGERT, Anita , ALMANSA-ROSALES, Carmen

IPC分类号： C07D207/16 , A61P29/00 , A61K31/165

摘要： The present invention relates to compounds showing pharmacological activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels.
More particularly, the invention relates to alkylaminoproline derivatives having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain and/or as neuroprotective agents.

5.

发明公开
NEW ALCOXYAMINOPYRIDINE DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS 审中-公开

公开(公告)号：EP3873901A1

公开(公告)日：2021-09-08

申请号：EP19805544.4

申请日：2019-11-04

申请人： ESTEVE PHARMACEUTICALS, S.A.

发明人： ALMANSA-ROSALES, Carmen , CUEVAS-CORDOBÉS, Félix

IPC分类号： C07D471/04 , A61P25/00 , A61P29/00 , A61K31/551

6.

发明公开
3,4-DIHYDRO-2H-SPIRO[ISOQUINOLINE-1,4'-PIPERIDIN]AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN 审中-公开

公开(公告)号：EP3858438A1

公开(公告)日：2021-08-04

申请号：EP20382069.1

申请日：2020-02-03

申请人： ESTEVE PHARMACEUTICALS, S.A.

发明人： ALMANSA-ROSALES, Carmen , OSORIO-PLANES, Laura

IPC分类号： A61P25/04 , A61K31/435 , C07D471/10

摘要： The present invention relates to new compounds that show pharmacological activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels or dual activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels, and the µ-opiod receptor (MOR or mu-opioid). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.

7.

发明公开
NEW ALKOXYAMINO COMPOUNDS FOR TREATING PAIN AND PAIN RELATED CONDITIONS 审中-公开

公开(公告)号：EP3697766A1

公开(公告)日：2020-08-26

申请号：EP18785986.3

申请日：2018-10-19

申请人： ESTEVE PHARMACEUTICALS, S.A.

发明人： ALMANSA-ROSALES, Carmen , CUEVAS-CORDOBÉS, Félix

IPC分类号： C07D309/14 , C07D333/16 , C07D405/06 , C07D409/12 , C07D409/14 , C07D241/42 , C07D487/04 , C07D295/096 , C07D211/58 , C07D211/76 , C07D295/192 , A61P25/04 , A61K31/381 , A61K31/496

8.

发明授权
ALKYL AND ARYL DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN 有权

公开(公告)号：EP3149007B1

公开(公告)日：2020-01-08

申请号：EP15726000.1

申请日：2015-06-02

申请人： ESTEVE PHARMACEUTICALS, S.A.

发明人： VIRGILI-BERNADO, Marina , ALONSO-XALMA, Monica , ALEGRET-MOLINA, Carlos , ALMANSA-ROSALES, Carmen , GARCIA LOPEZ, Monica

IPC分类号： C07D498/10 , C07D519/00 , A61K31/5386 , A61P29/00

9.

发明授权
N-(2-(3-(BENZYL(METHYL)AMINO)PYRROLIDIN-1-YL)ETHYL)-N-PHENYL)PROPIONAMIDE DERIVATIVES AND RELATED COMPOUNDS AS DUAL SIGMA 1 AND MU OPIOID RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN 有权

公开(公告)号：EP3328847B1

公开(公告)日：2019-09-11

申请号：EP16744665.7

申请日：2016-07-28

申请人： ESTEVE PHARMACEUTICALS, S.A.

发明人： GARCIA-LOPEZ, Monica , ALMANSA-ROSALES, Carmen

IPC分类号： C07D401/12 , C07D211/56 , C07D487/04 , A61K31/40 , A61K31/4439 , A61P25/04

10.

发明公开
OXADIAZASPIRO COMPOUNDS FOR THE TREATMENT OF DRUG ABUSE AND ADDICTION 审中-公开

公开(公告)号：EP3377500A1

公开(公告)日：2018-09-26

申请号：EP16797458.3

申请日：2016-11-15

申请人： ESTEVE PHARMACEUTICALS, S.A.

发明人： VIRGILI-BERNADO, Marina , ALMANSA-ROSALES, Carmen , ALEGRET-MOLINA, Carlos

IPC分类号： C07D498/10 , A61K31/5386 , A61P25/32 , A61P25/34 , A61P25/36

CPC分类号： C07D498/10 , A61P25/30

摘要： The present invention relates to compounds having pharmacological activity towards the sigma (σ) receptor, and more particularly to oxadiazaspiro compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular against drug abuse and addiction.