- 专利标题: CARBOXYLIC ACID-TYPE LIPID, AND LIPID PARTICLE AND LIPID MEMBRANE CONTAINING CARBOXYLIC ACID-TYPE LIPID
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申请号: EP19872471.8申请日: 2019-10-17
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公开(公告)号: EP3868740A1公开(公告)日: 2021-08-25
- 发明人: TAKEOKA, Shinji , NAKAHARA, Keiko , NISHIURA, Mamoru , OTSUBO, Shinya , KURUMATANI, Hajimu , ARAKANE, Toru
- 申请人: Toray Industries, Inc. , Nanotheta Co, Ltd.
- 申请人地址: JP Tokyo, 103-8666 1-1, Nihonbashi-muromachi, 2-chome Chuo-ku; JP Tokyo 169-0051 1-22-3, Nishiwaseda Shinjuku-ku
- 代理机构: Kador & Partner PartG mbB
- 优先权: JP2018196222 20181017
- 国际公布: WO2020080495 20200423
- 主分类号: C07C233/05
- IPC分类号: C07C233/05 ; A61K31/225 ; A61P7/04 ; C07K5/00 ; C07K7/00
摘要:
An object of the present invention is to provide a carboxylic acid-type lipid that can accelerate adhesion or aggregation of platelets even if the carboxylic acid-type lipid does not carry a protein involved in adhesion or aggregation of platelets, such as GPIb and H12, or a peptide corresponding to an active site of the protein; a lipid particle and a lipid membrane each comprising the carboxylic acid-type lipid; and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each comprising the carboxylic acid-type lipid, the lipid particle or the lipid membrane, and, in order to achieve the object, the present invention provides a carboxylic acid-type lipid selected from carboxylic acid-type lipids represented by formulas (I) to (VI), a lipid particle comprising the carboxylic acid-type lipid, a lipid membrane comprising the carboxylic acid-type lipid, and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each comprising the carboxylic acid-type lipid, the lipid particle or the lipid membrane.
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