- 专利标题： BISPECIFIC ANTI-CD19XCD3 T CELL ACTIVATING ANTIGEN BINDING MOLECULES
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申请号： EP21168389.1申请日： 2016-09-28
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公开(公告)号： EP3913000A1公开(公告)日： 2021-11-24
- 发明人: BACAC, Marina , KLEIN, Christian , SCHAEFER, Wolfgang , KLOSTERMANN, Stefan , IMHOF-JUNG, Sabine , MOLHOJ, Michael , REGULA, Joerg Thomas , UMAÑA, Pablo , HERTER, Sylvia , NEUMANN, Christiane
- 申请人： F. Hoffmann-La Roche AG
- 申请人地址： CH 4070 Basel Grenzacherstrasse 124
- 代理机构： Cueni, Leah Noëmi
- 优先权： EP16169160 20160511
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K16/46 ; A61K39/395 ; A61P35/00
摘要：
The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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