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公开(公告)号：EP3763739A1
公开(公告)日：2021-01-13
申请号：EP20163877.2
申请日：2015-05-22
发明人： NEUMANN, Christiane , LIFKE, Valeria , MOESSNER, Ekkehard , OFFNER, Sonja , PLATZER, Josef , TIEFENTHALER, Georg , RITTER, Mirko
IPC分类号： C07K16/28
摘要： One aspect as reported herein is using a method comprising the step of immunizing an experimental animal, three times with primary cynomolgus PBLs, whereby the PBLs are optionally enriched for T cells without using primary human PBLs as immunogen and without using a denaturing agent for producing a human cynomolgus cross-reactive antibody specifically binding to human CD3 epsilon of SEQ ID NO: 02 and specifically binding to a polypeptide of SEQ ID NO: 01, wherein the human cynomolgus cross-reactive antibody specifically binds to human and cynomolgus T cells, activates human T cells and does not bind to the same epitope as the antibody OKT3, the antibody UCHT1 and/or antibody the SP34.
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公开(公告)号：EP3356410A1
公开(公告)日：2018-08-08
申请号：EP16775649.3
申请日：2016-09-29
发明人： BACAC, Marina , FAUTI, Tanja , IMHOF-JUNG, Sabine , KLEIN, Christian , KLOSTERMANN, Stefan , MOESSNER, Ekkehard , MOLHOJ, Michael , NEUMANN, Christiane , REGULA, Joerg Thomas , SCHAEFER, Wolfgang , UMAÑA, Pablo
IPC分类号： C07K16/28 , C07K16/46 , A61K39/395 , A61P35/00 , C07K16/30
CPC分类号： C07K16/3007 , A61K2039/505 , C07K16/2809 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/66 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：EP4168444A1
公开(公告)日：2023-04-26
申请号：EP21731532.4
申请日：2021-06-17
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公开(公告)号：EP3356407A1
公开(公告)日：2018-08-08
申请号：EP16775194.0
申请日：2016-09-28
发明人： BACAC, Marina , KLEIN, Christian , SCHAEFER, Wolfgang , KLOSTERMANN, Stefan , IMHOF-JUNG, Sabine , MOLHOJ, Michael , REGULA, Joerg Thomas , UMANA, Pablo , HERTER, Sylvia , NEUMANN, Christiane
IPC分类号： C07K16/28 , C07K16/46 , A61K39/395 , A61P35/00
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/3007 , C07K16/3053 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/526 , C07K2317/55 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：EP4444756A1
公开(公告)日：2024-10-16
申请号：EP22835233.2
申请日：2022-12-08
发明人： BRANSI, Ali , CARPY GUTIERREZ CIRLOS, Alejandro , FREIMOSER-GRUNDSCHOBER, Anne , HOFER, Kerstin , HOFER, Thomas , KUEHNL, Tommy , MOESSNER, Ekkehard , NEUMANN, Christiane
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , A61P37/06 , C07K16/28
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公开(公告)号：EP4168456A1
公开(公告)日：2023-04-26
申请号：EP21731536.5
申请日：2021-06-17
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公开(公告)号：EP4263609A1
公开(公告)日：2023-10-25
申请号：EP21839881.6
申请日：2021-12-15
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公开(公告)号：EP4168445A1
公开(公告)日：2023-04-26
申请号：EP21731534.0
申请日：2021-06-17
发明人： AMANN, Maria , CARPY GUTIERREZ CIRLOS, Alejandro , CLAUS, Christina , CODARRI DEAK, Laura , DAROWSKI, Diana , FAUTI, Tanja , FERRARA KOLLER, Claudia , FREIMOSER-GRUNDSCHOBER, Anne , HERTER, Sylvia , HOFER, Thomas , KLEIN, Christian , LAUENER, Laura , LECLAIR, Stephane , MOESSNER, Ekkehard , NEUMANN, Christiane , UMAÑA, Pablo , SURÓWKA, Marlena , BRANSI, Ali
IPC分类号： C07K16/28 , C07K16/42 , A61K47/68 , A61P35/00 , C07K16/24 , C07K14/705 , C07K14/55 , A61K39/395
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公开(公告)号：EP3913000A1
公开(公告)日：2021-11-24
申请号：EP21168389.1
申请日：2016-09-28
发明人： BACAC, Marina , KLEIN, Christian , SCHAEFER, Wolfgang , KLOSTERMANN, Stefan , IMHOF-JUNG, Sabine , MOLHOJ, Michael , REGULA, Joerg Thomas , UMAÑA, Pablo , HERTER, Sylvia , NEUMANN, Christiane
IPC分类号： C07K16/28 , C07K16/46 , A61K39/395 , A61P35/00
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：EP3055329B1
公开(公告)日：2018-06-13
申请号：EP14781237.4
申请日：2014-10-08
发明人： BRUENKER, Peter , NEUMANN, Christiane , KLEIN, Christian , MOESSNER, Ekkehard , SCHAEFER, Wolfgang
CPC分类号： C07K16/40 , C07K16/2878 , C07K16/3053 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/60 , C07K2317/73
摘要： The present invention relates to multispecific antibodies based on antibodies that share a common light chain. The multispecific antibodies include modified heavy chains comprising by domain exchange a common light chain variable domain VL; and two modified light chains comprising by domain exchange variable heavy chain domains of a first antibody (VH1) and a second antibody (VH2), wherein one light chain is of kappa isotype and one light chain is of lambda isotype. The present invention also relates to methods for the manufacture of said antibodies and their use.
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